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Page 12 of 21 O’Connell et al. Microbiome Res Rep 2023;2:21 https://dx.doi.org/10.20517/mrr.2023.17
Figure 5. Proposed cluster assignments for cluster H. (A) VIRIDIC alignment of cluster H. The single Predatorvirus, Predator, does not
meet the ≥ 70% nucleotide similarity threshold for inclusion with the larger H1 genus, Konstantinevirus; (B) Gegenees proteome
alignment for cluster H. Predator also does not meet the proposed minimum proteome similarity threshold of 50% for inclusion in the
same subcluster as any member of the Konstantineviruses; (C) (i) Existing subcluster classifications of cluster H. H1 and H2 are
observable on two very distinct clades. Predator shares a clade with the other H1 viruses. (ii) Proposed subcluster creation for
Predatorviruses. While Predator shares a clade with the Konstantineviruses, the divergence of its branch from the other phages would
appear to reflect the < 50% proteome similarity noted in the Gegenees output, which would support the creation of a novel subcluster
(indicated in the red square).
