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Sawada et al. Mini-invasive Surg 2021;5:6  I  http://dx.doi.org/10.20517/2574-1225.2020.100                                 Page 5 of 11

               Table 1. Descriptive characteristics of the study population and tumor characteristics
                                               Cohort before PSM                      Cohort after PSM
               Variables            OPN (n = 71)  RAPN (n = 131) P value OPN (n = 58)  RAPN (n = 58)  P value SMD
                Age (yr)                                     0.065                            0.36  0.173
                 Mean (SD)          59.4 (14.1)  63.0 (12.7)        59.3 (13.4)  61.7 (14.3)
                Sex, n (%)                                   0.56                             0.83
                 Male               51 (71.8)    99 (75.6)          43 (74.1)    44 (75.9)
                 Female             20 (28.2)    32 (24.4)          15 (25.9)    14 (24.1)
                BMI, kg/m 2                                  0.006                            0.78  0.052
                 Mean (SD)          23.2 (4.1)   24.8 (3.8)         23.8 (4.2)   23.6 (3.5)
                Charlson comorbidity index, n                0.36                             0.90
                (%)
                 0                  35 (49.3)    76 (58.0)          30 (51.7)    29 (50.0)
                 1                  11 (15.5)    28 (21.4)          11 (19.0)    11 (19.0)
                 2                  19 (26.8)    20 (15.3)          15 (25.9)    14 (24.1)
                 ≥ 3                6 (8.4)      7 (5.3)            2 (3.4)      4 (6.9)
                               2
                eGFR (mL/min/1.73 m )                         0.35                            0.51  0.275
                 Median (IQR)       64.1 (45.1-86.0)  66.3 (56.6-77.0)  64.7 (47.1-86.0)  62.1 (54.9-73.3)
                Imperative case, n (%)  34 (47.9)  44 (33.6)  0.046  24 (41.3)   25 (43.1)    0.85
                Clinical stage, n (%)                        0.19                             1.00
                 cT1a               55 (77.5)    111 (84.7)         49 (84.5)    49 (84.5)
                 cT1b               13 (18.3)    20 (15.3)          9 (15.5)     9 (15.5)
                 cT2a-b             2 (2.8)      0 (0)              0 (0)        0 (0)
                Tumor size (cm)                              0.26                             0.63  0.089
                 Median             3.0          2.7                2.5          3.0
                 IQR                2.1-3.9      2.0-3.5            1.8-3.6      2.0-3.7
                Tumor side, n (%)                            0.45                             1.00
                 Left               37 (52.1)    61 (46.6)          28 (48.3)    28 (48.3)
                 Right              34 (47.9)    70 (53.4)          30 (51.7)    30 (51.7)
                RENAL nephrometry score
                 Radius, n (%)                               0.08                             0.80
                  ≤ 4 cm            54 (76.1)    111 (84.7)         49 (84.5)    48 (82.8)
                  4-7 cm            15 (21.1)    20 (15.3)          9 (15.5)     10 (17.2)
                  ≥ 7 cm            2 (2.8)      0 (0)              0 (0)        0 (0)
                 Exophytic/endophytic                        0.17                             0.71
                  ≥ 50% Exophytic   25 (35.2)    53 (40.5)          20 (34.5)    23 (39.7)
                  < 50% Exophytic   33 (46.5)    66 (50.4)          27 (46.6)    27 (46.4)
                  Endophytic        13 (18.3)    12 (9.1)           11 (19.0)    8 (13.8)
                 Nearness to the collecting                  0.25                             0.90
                 system
                  ≥ 7 mm            15 (21.1)    42 (32.1)          14 (24.1)    12 (20.7)
                  4-7 mm            16 (22.5)    24 (19.8)          11 (19.0)    11 (19.0)
                  ≤ 7 mm            40 (56.3)    65 (49.6)          33 (56.9)    35 (60.3)
                 Anterior/posterior, n (%)                   0.52                             0.23
                  Anterior          37 (52.1)    60 (45.8)          30 (51.2)    28 (26)
                  Posterior         29 (40.9)    56 (42.3)          24 (41.4)    31 (53.5)
                 Location relative to the polar              0.02                             1.00
                 lines
                  Above or below the polar  16 (22.5)  56 (42.8)    16 (27.6)    16 (27.6)
                  line
                  Lesion crosses the polar   33 (46.5)  44 (33.6)   23 (39.7)    23 (39.7)
                  line
                  > 50% is across the polar  22 (31.0)  31 (23.7)   19 (32.8)    19 (32.8)
                  line and crosses the axial
                  midline entirely between
                  the polar lines
                Total score, mean (SD)  7.5 (1.56)  6.8 (1.61)  0.003  7.4 (1.58)  7.4 (1.51)  0.95  0
               RAPN: Robot-assisted partial nephrectomy; OPN: open partial nephrectomy; PSM: propensity score matching; eGFR: estimated
               glomerular filtration rate; SD: standard deviation; IQR: interquartile range; SMD: standardized mean difference; Imperative case: single
               kidney, bilateral tumors, or chronic kidney disease (eGFR < 60).
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