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Figure 8. Meta-analysis of need for re-intervention
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Figure 9. Meta-analysis of time to first flatus
Subgroup analysis on left colectomy
In our systematic review, only three studies were found to have met the search criteria with direct
comparison on anastomotic leakage between intracorporeal and extracorporeal anastomosis in left-
sided colectomy. After a careful review, only two studies [29,33] were eligible for further analysis, with a total
number of 233 patients (125 IA vs. 108 EA). A meta-analysis was conducted for the primary outcome of
anastomotic leak, which did not demonstrate a significant difference between the two cohorts (OR = 1.90;
2
95%CI: 0.27-13.21; P = 0.52; I = 0%) [Figure 12]. However, these studies were non-randomised with a
lack of long-term follow-up, and it was perceived that further subgroup meta-analysis on left colectomy
[29]
alone, with Milone et al. imposing significantly higher weight (64.4%), would be unlikely to produce
meaningful results and therefore was not conducted.
