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Park et al. Mini-invasive Surg 2020;4:87 I http://dx.doi.org/10.20517/2574-1225.2020.87 Page 5 of 16

Anastomosis Side-to-Side Linear Stapler for IA; Variations in EA Side-to-Side Linear Stapler Side-to-Side Linear Stapler; Isoperistaltic Side-to-Side Linear Stapler; Isoperistaltic Linear Stapler Side-to-Side Linear Stapler; Isoperistaltic Linear Stapler; Isoperistaltic Linear Stapler Side-to-Side Linear or Circular Stapler Side-to-Side Linear Stapler; Isoperistaltic Side-to-Side Linear Stapler Side-to-Side Linear Stapler; Anti

Malignant Malignant (EA) (IA) 87.1% 77.1% 84.8% 64.1% 100% 88.9% 72% 62.9% NR NR 100% 100% 100% 100% 100% 100% 29.4% 24.1% 65.1% 82.6% 63.2% 65.2% 100% 100% 100% 100% 63% 60.7% NR NR 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% NR NR 100% 100% 85.9% 82.8%

BMI (EA) 25.6 ± 1.6 28.3 ± 4.3 26.3 ± 3.2 26.7 ± 3.9 20.6 ± 1.7 25.8 ± 3.2 22.1 ± 1.6 NR 23.4 25.5 ± 1.4 28.5 ± 5 28.6 ± 6.8 23.9 ± 4.4 26.2 26.1 ± 3.3 25.4 ± 3.8 24.7 ± 4.2 26.3 ± 3.8 28 26.9 ± 4.3 25 ± 3.6 28.6 24.8 ± 3.4 31.6 ± 2.2

BMI (IA) 24.8 ± 1.6 27.4 ± 4.3 25.6 ± 4.7 25.9 ± 3.1 20.3 ± 2 27 ± 3.5 21.4 ± 2.3 NR 23.8 26.1 ± 1.1 28.8 ± 5.3 29 ± 7.1 24.8 ± 2.8 26.1 24.3 ± 5.9 25.2 ± 3.8 29.5 ± 4.3 26 ± 4 27 27.8 ± 4.6 25.4 ± 3.9 21.7 24.6 ± 4.3 31.4 ± 2

Age (EA) 71.5 ± 3 74 ± 12 68.6 ± 9.8 58.9 ± 12.9 69 ± 6.5 63.3 ± 13 59.4 ± 9.5 NR 50 59 ± 4.5 66.5 ± 14 66 ± 11.3 71.2 ± 10.5 67.7 65 ± 14.5 65.6 ± 11.4 68.7 ± 10.2 63.7 ± 10.3 68.5 ± 10 72 ± 6.8 72.7 ± 2.1 69 64.7 ± 2.9 63.5 ± 13.5

Age (IA) 70.5 ± 3 74.5 ± 9 69.5 ± 12.7 62.2 ± 13.4 68 ± 8.3 65.4 ± 9.6 62.1 ± 8.3 NR 45 66 ± 4 65.8 ± 8.8 70 ± 11.8 70.9 ± 13.4 66.2 64.3 ± 10.3 66.7 ± 12.6 66 ± 10.9 63.5 ± 10.3 65.7 ± 11 72 ± 7.5 64.2 ± 12.4 65 67.4 ± 1.8 61.3 ± 13.3

IHE quality score 23 22 24 22 23 21 24 22 27 25 27 25 24 28 28 25 24 26 22 22 24

Multi- centre N N N N N N N N N Y N Y N N N Y Y N N Y N N N N

EA (n) 70 33 54 25 29 15 50 10 51 109 57 35 40 27 30 226 89 30 40 100 19 29 30 64
IA (n) 70 39 54 35 56 15 50 82 54 86 23 51 40 28 30 286 92 42 40 91 33 21 30 64
Location Right Right Right Right Right Right Right Right Right Right Right Right Right Right Right Right Left Right Right Right Left Right Right Right

Study design Double-blind randomised Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Retrospective Prospective Retrospective Prospective randomised Prospective Retrospective Retrospective Retrospective Prospective Retrospective Retrospective Prospective randomised Retrospective IA: intracorporeal anastomosis; EA: extracorporeal an

Table 1. Study characteristics and demographic data

Country Italy Italy Italy Spain China Turkey Italy USA USA USA USA USA Italy Italy Italy Italy Italy Italy Italy Israel Israel Canada Italy Italy

Recruitment 2017-2018 2006-2010 2006-2016 2004-2010 2011-2015 NR 2001-2009 1991-2002 2006-2008 2005-2014 2004-2008 2005-2010 2009-2011 2006-2010 2015-2016 2005-2012 2005-2015 2006-2011 2006-2009 2006-2014 2005-2014 2008-2009 2008-2015 2008-2015

Year 2019 2012 2017 2011 2016 2013 2010 2004 2010 2015 2009 2013 2013 2013 2018 2015 2018 2012 2010 2016 2016 2015 2016 2018

Allaix et al. [14] Anania et al. [15] Biondi et al. [16] Chaves et al. [17] Jian-Cheng et al. [18] Erguner et al. [19] Fabozzi et al. [20] Franklin et al. [21] Grams et al. [22] Hanna et al. [23] Hellan et al. [24] Lee et al. [25] Magistro et al. [26] Marchesi et al. [27] Mari et al. [28] Milone et al. [7] Milone et al. [29] Roscio et al. [30] Scatizzi et al. [31] Shapiro et al. [32] Swaid et al. [33] Vergis et al. [34] Vi