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Page 12 of 17 Cannata et al. Mini-invasive Surg 2020;4:53 I http://dx.doi.org/10.20517/2574-1225.2020.41

1 death due to non- cardiovascular causes 57 days after MitraClip 1 left-ventricular assist device implantation 60 days after MitraClip Deaths = 4 (26- 282 days) Median follow-up = 15 months Death = 1 (3 weeks after discharge)

Deaths = 0 Death (6th day) = 1 Resolution of shock = 10 Inotrope- dependent = 1 Death = 1

53 ± 33 days from Device success = 5/5 admission 1 clip = 2 2 clips = 3 - N of clips = 2.3 ± MR grade 0 = 1 1+ = 8 2+ = 3 MV MG = 5.0 ± 2.7 mmHg LVEDD = 5.4 ± 0.8 cm LVEF = 37 ± 15% Device success = Days after MI = 19/20 32 (7-90) In one patient, a Clips = 1 – 3 posterior leaflet MR grade 1+ = 12 tear occurred MR grade 2+ = 7 after the second PAP = 40 ± 13 clip implantation and urgent MV v-wave = 17 ± 5 replacement

Cardiogenic shock = 4 Pulmonary edema = N of clips: • 1 • Median Euroscore IABP and inotropes = 4 Cardiogenic shock 0.7 - IABP + inotropes = 3 • - IABP + • nitroprusside = 1 • - inotropes + nitroprusside = 1 - inotropes = 6 - nitroprusside = 1 - ECMO = 1 Mean LAP = 27 ± 9 Mean PAP = 38 ± 11 Mean sPAP = 57 ± 17 Mean RAP = 13 ± 5 CI = 2.2 ± 0.5 CO = 4.3 ± 1.2 Cardiogenic shock = 8 sPAP = 60 ± 12 mmHg v-wave = 3

N of patients = 5 Age = 73 ± 6 years Males = 3 = 27.1 ± 13% Median STS score Inotropes = 1 = 10.2 ± 6% 5/79 MitraClip procedures (6.3%) Period: 10/2010- 10/2015 N of patients = 12 Age = 71.7 ± 12.8 Males = 9 LVEF = 46 ± 12% STS score (MV repair) = 33.4 ± 22.3% STS score (MV replacement) = 23.9 ± 18.2% 12/135 MitraClip procedures (9%) Period: 11/2013- 10/2018 N of patients = 20 Age = 68 ± 10 years Males = 6 (30%)

AMI without papillary muscle rupture: • 3 STEMI • 2 NSTEMI Cardiogenic shock: AMI = 3 • acute papillary muscle years • rupture = 1 chordal rupture = 1 • acute leaflet flail = 1 • acute worsening • of functional and degenerative MR = 1 acute worsening of • functional MR = 1 AMI within 90 days: • 12 STEMI • 8 NSTEMI • 11 anterior • 9 inferior-posterior No evidence of structural LVEF = 35.9 ± valvular damage

Adamo et al. [40] Flint et al. [41] Haberman et al. [42]

Percutaneous edge-to- edge mitral valve repair for the treatment of acute mitral regurgitation complicating myocardial infarction: A single centre experience Percutaneous edge- to-edge mitral valve repair may rescue select patients in cardiogenic shock: findings from a single center case series Salvage MitraClip in severe secondary mitral regurgitation complicating acute myocardial infarction: data from a multicentre interna