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Page 6 of 11                                  Serra-Aracil et al. Mini-invasive Surg 2019;3:37  I  http://dx.doi.org/10.20517/2574-1225.2019.36

               Table 3. Descriptive surgical, postoperative and pathological variables
                                                                                        Overall patients
                Variables
                                                                                           n = 716
                Surgical      Anesthesia type                General              655 (91.4%)
                                                             Locoregional         61 (8.6%)
                              Surgical equipment             TEM                  349 (48.7%)
                                                             TEO                  367 (51.3%)
                              Fragmentation of the specimen  En bloc              658 (91.9%)
                                                             Piecemeal            58 (8.1%)
                              Surgical time(min) (median-IQR-range)               70 (IQR 50) (range 17-265)
                              Perforation into abdominal cavity                   51 (7.1%)
                              Vaginal perforation                                 12 (1.7%)
                              Suture of the defect after excision  Complete       614 (85.8%)
                                                             Incomplete           94 (13.1)
                                                             Absent               8 (1.1%)
                              Conversion to abdominal surgery                     1 (0.1%)
                Postoperative   Overall morbidity                                 158 (22.1%)
                              Morbidity (Clavien-Dindo)      0                    558 (77.9%)
                                                             I                    98 (13.7%)
                                                             II                   24 (3.4%)
                                                             IIIa                 11 (1.5%)
                                                             IIIb                 17 (2.4%)
                                                             Iva                  5 (0.7%)
                                                             IVb                  1 (0.1%)
                                                             V (mortality)        2 (0.3%)
                              Clinically relevant morbidity (Cl-D > II)           36 (5%)
                              CCI                                                 0 (IQR 0) (range 0-100)
                              Asymptomatic fever post-TEM                         59 (8.2%)
                Pathology     Definitive pathology           Adenoma              422 (58.9%)
                                                             Adenocarcinoma       239 (33.4%)
                                                             No pathology         55 (7.7%)
                              Positive margin                                     61 (8.6%)
                              Wall excision                  Full-thickness       710 (99.2%)
                                                             Partial              6 (0.8%)
               TEM: transanal endoscopic microsurgery; TEO: transanal endoscopic operation; IQR: interquartile range; Cl-D: Clavien-Dindo; CCI:
               comprehensive complex index


               Urinary complications were relatively uncommon, being recorded in 30/716 (4.2%) patients. Nine of 716
               (1.3%) patients presented urine infections and 20 (2.8%) patients presented acute urine retention (AUR).


               Infectious complications were rare (14/716, 2%). Pelvic or perianal abscess occurred in seven (1%) patients
               and were treated by antibiotics and local debridement, except in two cases that required colostomy. All
               of them were associated with tumors located in the lower third of the rectum. In the cases that required
               colostomy, one was an immunosuppressed patient with lymphoma who developed perineal cellulitis. In the
               other patient, with no history of interest, a perianal abscess was observed on Postoperative Days 4-5; after
               local debridement, the perianal infection progressed, obliging the creation of a colostomy.


               Two patients underwent exploratory laparotomy, one for severe pneumoperitoneum on chest X-ray [Figure 2],
               and the other due to massive neuro-retroperitoneum on abdominal CT [Figure 3]. The abdominal CT did
               not record any free intra-abdominal fluid or collections. In neither case was rectal perforation observed, or
               the presence of intestinal contents.


               DISCUSSION
               Postoperative surgical complications after TEM are rare and tend to be unimportant. In this study, 98/158
               (62.1%) complications recorded were Cl-D grade I, and only 5% of patients presented clinically relevant
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