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Page 4 of 12                                           Young et al. Mini-invasive Surg 2018;2:16  I  http://dx.doi.org/10.20517/2574-1225.2017.50

               Table 1. Selected studies
                Author                           Year            Country                  Size
                Lapolla et al. [13]              2010            USA                    120/83
                Abenhaim et al. [14]             2016            USA                    221,580/9587
                Adams et al. [15]                2015            USA                    10,447/2666
                Amsalem et al. [16]              2014            Israel                 109/109
                Aricha-Tamir et al. [17]         2012            Israel                 144/144
                Berlac et al. [18]               2014            Denmark                826/415
                Ducarme et al. [19]              2007            France                 414/13
                Johannsson et al. [20]           2015            Sweden                 2356/596
                Kjaer et al. [21]                2013            Sweden                 1277/339
                Parker et al. [22]               2016            USA                    185,120/1585
                Patel et al. [23]                2008            USA                    43/26
                Santulli et al. [24]             2010            France                 120/24
                Stephanson et al. [25]           2016            Sweden                 447/163


               Of the 13 studies, 5 were from the USA, 3 were from Sweden, 2 were from France, 2 were from Israel, and 1
               was from Denmark. All studies included obese controls as well as post-surgical women who are obese and
               were published within the last 10 years [Table 1].


               Primary outcomes
               The primary outcome of cesarean section rates included 10 papers [13,14,16-19,21-24]  and had 230,994 women in the
               control population and 5571 women in the post-surgical population. As compared to the control population,
               there was a decrease in the rates of cesarean sections found among the post-surgical population [odds ratio
               (OR) 0.623, 95% confidence interval (CI) 0.600-0.646, P = 0.000] [Figure 2].


               Secondary outcomes
               The secondary outcomes evaluated included: pregnancy-induced hypertension (PIH), gestational diabetes
               (GD), intra-uterine growth restriction (IUGR), SGA, LGA, macrosomia, assisted delivery, and premature
               delivery.

               The PIH review included 8 papers [13,14,16,18,19,22-24]  and had 89,952 women in the control population and 3094
               women in the post-surgical population. As compared to the control population, there was an increase in the
               rates of PIH in the post-surgical population (OR 1.113, 95% CI 1.067-1.161, P = 0.000) [Figure 3].

               The GD review included 9 papers [13,14,16,18-23]  and had 57,939 women in the control population and 1217 women
               in the post-surgical population. As compared to the control population, there was no difference in the rates
               of gestational diabetes in the two groups of patients (OR 1.046, 95% CI 0.984-1.112, P = 0.145) [Figure 4].


               The IUGR review included 5 papers [14,16,22-24]  and had 8357 women in the control population and 452 women
               in the post-surgical population. As compared to the control population, there was an increase in the rates of
               IUGR in the post-surgical population (OR 2.099, 95% CI, 1.904-2.315, P = 0.000) [Figure 5].


               The SGA neonates review included 6 papers [13,15,19-21,23]  and had 816 women in the control population and
               428 women in the post-surgical population. As compared to the control population, there was an increase
               in the rates of Small for Gestational Age neonates in the post-surgical population (OR 2.305, 95% CI 2.036-
               2.611, P = 0.000) [Figure 6].


               The LGA review included 5 papers [13,15,20-22]  and had 15,869 women in the control population and 412 women
               in the post-surgical population. As compared to the control population, there was a reduction in the rates of
               LGA babies found in the post-surgical population (OR 0.491, 95% CI 0.441-0.547, P = 0.000) [Figure 7].
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