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Erodotou et al. Mini-invasive Surg 2023;7:35  https://dx.doi.org/10.20517/2574-1225.2023.95                                 Page 5 of 12

               Table 1. Characteristics of included studies
                                               Number
                                     Type of                  Pre-existing                 Observation            Learning curve
                Author   Year Region           of      Robot                  Procedure               Assisting cases            Learning curve plateau
                                     study     patients       experience                   cases                  analysis method
                Chao et al. [32]  2020 USA  Retrospective 39  Da Vinci  MIE   McKeown; Robotic  NR    NR          CUSUM          12 cases for safe lymph node
                                                       Si/Xi                  thoracic phase                                     dissection along the left
                                                                                                                                 recurrent laryngeal nerve
                      [33]
                Duan et al.  2020 China  Retrospective 70  Da Vinci  Open/MIE  McKeown; Robotic  NR   NR          CUSUM          43 cases for safe lymph node
                                                       Si/Xi                  thoracic and                                       dissection along the left
                                                                              abdominal phase                                    recurrent laryngeal nerve
                Fuchs et al. [24]  2019 Germany  Prospective  70  Da Vinci  30 Simple training   Ivor Lewis; Robotic  NR  NR  Cohort comparison  NR
                                                       Xi     robotic procedures with  thoracic phase
                                                              increasing difficulty
                                                              Modular step-up
                                                              approach
                Grimminger  2019 Germany  Prospective  25  Da Vinci  Hybrid and MIE  Ivor Lewis; Robotic  NR  NR  Consecutive 25-  NR
                et al. [30]                            Xi                     thoracic phase                      patient cohort
                                                                                                                  comparison RAMIE
                                                                                                                  vs. MIE vs. hybrid
                Han et al. [16]  2022 USA  Retrospective 124  Da Vinci  MIE   Ivor Lewis; Robotic  NR  NR         CUSUM/ RA-CUSUM 73 cases for increased lymph
                                                       S                      thoracic and                                       node yield
                                                                              abdominal phase
                                                                                                                                 46 cases for decreased total
                                                                                                                                 operation time
                                                                                                                                 39 cases for decreased
                                                                                                                                 abdominal operation time
                                                                                                                                 55 cases for decreased
                                                                                                                                 thoracic operation time
                                                                                                                                 29 cases for stapled
                                                                                                                                 anastomoses
                                                                                                                                 15 cases for hand sewing
                                                                                                                                 anastomosis
                                                                                                                                 51 cases for decreased major
                                                                                                                                 complication rates
                Hernandez    2013 USA  Prospective  52  Da Vinci MIE          Ivor Lewis; Robotic  NR  NR         Comparison of   20 cases for decreased total
                etal. [26]                                                    thoracic and                        successive 10-patient  operating time
                                                                              abdominal phase                     cohorts
                Hsieh et al. [19]  2022 Taiwan  Retrospective  179  Da Vinci  Open esophagectomies  McKeown; Robotic  NR  50  CUSUM  41 cases for decreased
                                                       S/Si/Xi  Thoracoscopic   thoracic phase                                   thoracic operating time from
                                                              lung/mediastinal                                                   the surgeon with pree-existing
                                                              operations                                                         > 150 VATE experience
                                                              VATE                                                               (surgeon A)
                                                                                                                                 32 cases for decreased
                                                                                                                                 thoracic operating time from
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