Page 48 - Read Online

Page 6 of 7 Carilli et al. Mini-invasive Surg 2024;8:9 https://dx.doi.org/10.20517/2574-1225.2023.132

Nevertheless, we believe that even a single-centre experience on a small cohort of patients can add useful
data to a literature that inevitably suffers from the rarity of such condition. We believe our results seem
encouraging, highlighting a small impact on early renal functional outcomes from the modifications
suggested with respect to a “conventional” technique for RAPN.

In conclusion, our case series showed the feasibility of off-clamp RAPN in patients with multiple ipsilateral
renal tumours in experienced hands. Further studies with larger sample size and longer follow-up are
warranted to better define the optimal management strategy in such an uncommon scenario.

DECLARATIONS
Author contributions
Study concept and design: Carilli M, Bertolo R, Bove P
Data acquisition: Carilli M, Vittori M, Iacovelli V, Antonucci M, Signoretti M, Maiorino F, Petta F
Data analysis: Carilli M, Bertolo R
Drafting of manuscript: Carilli M, Bertolo R, Vittori M
Critical revision of the manuscript: Carilli M, Bertolo R, Vittori M, Iacovelli V, Antonucci M, Signoretti M,
Maiorino F, Petta F, Bove P

Conflict of interest
All authors declared that there are no conflicts of interest.

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Ethical approval and consent to participate
This study was approved by the institutional research ethical committee (STS CE Lazio 1/Oss-552) and all
related procedures were conducted in accordance with the Declaration of Helsinki. Written informed
consent was obtained from all patients.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2024.

REFERENCES
1. Antonelli A, Cindolo L, Sandri M, et al; AGILE Group (Italian Group for Advanced Laparo-Endoscopic Surgery). Safety of on- vs off-
clamp robotic partial nephrectomy: per-protocol analysis from the data of the CLOCK randomized trial. World J Urol 2020;38:1101-8.
DOI PubMed
2. Bertolo R, Simone G, Garisto J, et al. Off-clamp vs on-clamp robotic partial nephrectomy: perioperative, functional and oncological
outcomes from a propensity-score matching between two high-volume centers. Eur J Surg Oncol 2019;45:1232-7. DOI PubMed
3. Brassetti A, Cacciamani GE, Mari A, et al. On-clamp vs. off-clamp robot-assisted partial nephrectomy for cT2 renal tumors:
retrospective propensity-score-matched multicenter outcome analysis. Cancers 2022;14:4431. DOI PubMed PMC
4. Antonelli A, Veccia A, Francavilla S, et al. On-clamp versus off-clamp robotic partial nephrectomy: a systematic review and meta-
analysis. Urologia 2019;86:52-62. DOI PubMed
5. Shrivastava N, Sharma G, Ahluwalia P, et al; European Association of Urology Young Academic Urologists Renal Cancer Study
Group. Off-clamp versus on-clamp robot-assisted partial nephrectomy: a systematic review and quantitative synthesis by the european