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Cho et al. Mini-invasive Surg 2021;5:20 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2021.11

Review Open Access

Therapeutic EUS

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Sung Hyun Cho , Dongwook Oh , Dong-Wan Seo
Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea.
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Authors contributed equally.
Correspondence to: Dr. Dong-Wan Seo, Department of Gastroenterology, University of Ulsan College of Medicine, Asan
Medical Center, 88-Olympic-Ro 43-Gil, Songpa-gu, Seoul 05505, South Korea. E-mail: dwseoamc@amc.seoul.kr
How to cite this article: Cho SH, Oh D, Seo DW. Therapeutic EUS. Mini-invasive Surg 2021;5:20.
https://dx.doi.org/10.20517/2574-1225.2021.11
Received: 31 Jan 2021 First Decision: 15 Mar 2021 Revised: 22 Mar 2021 Accepted: 29 Mar 2021 Published: 8 May 2021

Academic Editor: Jean François Rey Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen

Abstract
Currently, the standard treatment for pancreatic neoplasms is surgical resection. However, pancreatic surgical
resection is associated with high morbidity and mortality. Patients unfit for surgery are undergoing regular cross-
sectional imaging surveillance. Controversy surrounds the optimal surveillance of patients with pancreatic
neoplasms, underlying the need for minimally invasive treatment modalities as an alternative to surgical treatment.
To date, endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an emerging minimally invasive
therapeutic alternative to surgical resection for various pancreatic neoplasms. We review evaluations of EUS-RFA
for various pancreatic neoplasms to better understand its effectiveness and safety.

Keywords: Pancreatic neoplasm, endoscopic ultrasound, radiofrequency ablation

INTRODUCTION
Endoscopic ultrasound (EUS) is widely used to diagnose biliopancreatic diseases. The development of EUS-
guided fine needle aspiration (EUS-FNA) in the early 1990s has expanded EUS-guided interventions. After
the development of the linear echoendoscope and the increasing sizes of the EUS devices’ working channels,
EUS has recently evolved to become a therapeutic method for patients with biliopancreatic disease .
[1]

Although surgical resection has been the only curative treatment for various pancreatic tumors, pancreatic
surgery is related with high morbidity and mortality . The recent advance of the EUS device has led to an
[2,3]
increase in EUS-guided local treatment for pancreatic tumors. Radiofrequency ablation (RFA) is a local

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
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