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Page 6 of 13 Lesch et al. Mini-invasive Surg 2023;7:25 https://dx.doi.org/10.20517/2574-1225.2023.31

Table 2. Top: Overview of the 16 experimental series presented here, with ten valid experiments in each series, totaling 160
experiments, with the experimental boundary conditions and the likelihood of a secure closure (LOSC) Bottom: Explanation of the
abbreviations in the title of the experimental series (ES)
Defect Mesh SSSB / Amount of S:W-
Series Title Tissue Defect shape size size Suture LSLB Standardi- stitches L- LOSC
(cm) (cm) USP suture zation (n) Ratio (%)
ES 1 240-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 30
DMesh
ES 2 210-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 50
DMesh
ES 3 180-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 70
DMesh
ES 4 150-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 40
DMesh
ES 5 120-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 90
DMesh
ES 6 210-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 20
DMesh-40off
ES 7 210-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - -
DMesh-80off
ES 8 150-0.1sP-DC5- bovine circular 5 15 × 15 - - - - - 70
DMesh-
1000DIS
ES 9 210-0.2sP-DC5- bovine circular 5 15 × 15 - - - - - 40
DMesh
ES 10 180-0.2sP-DC5- bovine circular 5 15 × 15 - - - - - 30
DMesh
ES 11 150-0.2sP-DC5- bovine circular 5 15 × 15 - - - - - 40
DMesh
ES 12 210-0.4sP-DC5- bovine circular 5 15 × 15 - - - - - 0
DMesh
ES 13 180-0.4sP-DC5- bovine circular 5 15 × 15 - - - - - 20
DMesh
ES 14 210-0.1sP- porcine incision+circular 15 + 5 - 2-0 SSSB yes 21 4.1 100
INDC5-PDS20-
SBs
ES 15 210-0.1sP- porcine incision+circular 15 + 5 - 2-0 SSSB yes 27 4.5 90
INDC5-MM20-
SBs-cO
ES 16 210-0.1sP- porcine incision+circular 15 + 5 - 2-0 SSSB yes 23.5 4.3 40
INDC5-PDS20-
SBs-cO
® ®
240/210/180/150/120 Peak pressure (mmHg) PDS20 / MM20 USP 2-0 suture PDS or MonoMax
0.1/0.2/0.4 sP Length of pressure plateau (s) cO Circular opening of fixation plate (A = 490
2
cm )
DC5 Defect circular 5 cm 40/80 off 40 or 80 mmHg offset pressure
INDC5 Incision 15 cm + defect circular 5 1000 DIS 1000 DIS were conducted
cm
®
Dmesh DynaMesh Cicat 15 ×15 cm

The likelihood of a secure closure measures how many out of ten reconstructions (in %) withstood the
number of impacts (n) given on the x-axis.

Figure 3 shows that, in this case, an exclusively bridged 5 cm round defect with a sublay mesh is an unstable
reconstruction. Only low peak pressures, such as 120 mmHg or 150 mmHg, can be withstood with failure
rates lower than 20 % (circle and square graph). The mesh dislocates in up to 70 % of the cases when the
peak pressure rises to 240 mmHg (rhombic graph). When lowering the peak pressure by 30 mmHg, the