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Tsuboi et al. Mini-invasive Surg 2024;8:26 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2023.94

Review Open Access

Capsule endoscopy: clinical insights, challenges,

and evolving perspectives in the 21st century

1
Akiyoshi Tsuboi 1 , Shiro Oka , Shinji Tanaka 2
1
Department of Gastroenterology, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
2
Department of Gastroenterology, JA Onomichi General Hospital, Onomichi 722-0018, Japan.
Correspondence to: Dr. Akiyoshi Tsuboi, Department of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi,
Minami-ku, Hiroshima 734-8551, Japan. E-mail: atsuboi@hiroshima-u.ac.jp

How to cite this article: Tsuboi A, Oka S, Tanaka S. Capsule endoscopy: clinical insights, challenges, and evolving perspectives in
the 21st century. Mini-invasive Surg 2024;8:XX. https://dx.doi.org/10.20517/2574-1225.2023.94

Received: 6 Aug 2023 First Decision: 6 Jun 2024 Revised: 19 Oct 2024 Accepted: 29 Oct 2024 Published: 4 Nov 2024

Academic Editor: Giulio Belli Copy Editor: Ting-Ting Hu Production Editor: Ting-Ting Hu

Abstract
Capsule endoscopy (CE) is widely employed in clinical practice owing to its minimally invasive nature and high
diagnostic accuracy. It is the primary modality for evaluating suspected diseases of the small-bowel, as
recommended by guidelines from various countries. Advancements in CE technology have introduced various
models for evaluating not only the small-bowel but also the colon, esophagus, stomach, and the entire
gastrointestinal tract. Moreover, colon CE enables early detection of colorectal polyps and cancers, as well as
surveillance of inflammatory bowel disease. Furthermore, innovative developments, such as magnetically
controlled CE, offer enhanced maneuverability, particularly in the stomach. Recent reports highlight the growing
use of artificial intelligence in CE, with promising potential for reducing physician burden, and clinical
implementation is anticipated. Furthermore, novel CE technologies are expected to enable the diagnosis of
gastrointestinal diseases through a less invasive approach in the near future.

Key questions/aims: Herewith we provide a comprehensive review of the current status and clinical applications
of CE while addressing the challenges that remain in its implementation in practice and highlighting the key areas
for future research and development.

Keywords: Capsule endoscopy, small-bowel, magnetically controlled capsule endoscope, artificial intelligence

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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