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George et al. Mini-invasive Surg 2024;8:4  https://dx.doi.org/10.20517/2574-1225.2023.102                                                                               Page 5 of 23



                                                                                                                                      160 normal ones
                                           [11]
                              Pogorelov et al.   Active GI     2019          Retrospective Malaysia/   Combining colour features in RGB   Training: 300 bleeding frames and   SVM    Sensitivity of 97.6%,
                                                 bleeding                                 Norway      and texture features for bleeding   200 non-bleeding                           specificity of 95.9%
                                                                                                      detection                       Testing: 500 bleeding and
                                                                                                                                      200 non-bleeding frames
                                             [15]                                                                                                            [110]
                              Hajabdollahi et al.  Active GI   2019          Retrospective Iran       Developing a low-complexity CNN  Training and testing on KID         CNN       Sensitivity of 94.8%,
                                                 bleeding                                             method                                                                         specificity of 99.1%
                              Kanakatte and      Active GI     2021          Prospective  India       Proposing compact U-Net model   Training: 700 bleeding and           CNN       Sensitivity of 99.57%,
                                    [16]
                              Ghose              bleeding                                                                             700 non-bleeding                               specificity of 91%
                                                                                                                                      Testing: 50 capsule endoscopy images
                              Rathnamala and     Active GI     2021          Retrospective India      Utilising gaussian mixture model   Training: 686 bleeding and        SVM       Sensitivity of 99.83%,
                                    [12]
                              Jenicka            bleeding                                             superpixels for bleeding detection  961 non-bleeding images                    specificity of 100%
                                                                                                                                      Testing: 487 bleeding images and
                                                                                                                                      1,160 non-bleeding images
                              Ghosh and          Active GI     2021          Retrospective America    Develop CNN-based framework for  Alex-Net training: 1,410            CNN       Sensitivity of 97.51%,
                                       [17]
                              Chakareski         bleeding                                             bleeding identification         Alex-Net testing: 940                          specificity of 99.88%
                                                                                                                                      SegNet training: 201
                                                                                                                                      SegNet testing: 134
                                        [18]
                              Ribeiro et al.     Active GI     2021          Retrospective Portugal   Automatic detection and         Training: 820 images with red spots,   CNN     Sensitivity of 91.8%,
                                                 bleeding                                             differentiation of vascular lesions  830 images with angiodysplasia/varices,   specificity of 95.9%
                                                                                                                                      7,620 images with normal mucosa
                                                                                                                                      Testing: 206 images with red spots,
                                                                                                                                      207 images with angiodysplasia/varices,
                                                                                                                                      1,905 images with normal mucosa
                              Mascarenhas Saraiva  Active GI   2022          Retrospective Portugal   Create CNN-based system for     Training: 10,808 images containing blood,  CNN  Sensitivity of 98.6%,
                                  [19]
                              et al.             bleeding                                             automatic detection of blood or   6,868 with normal mucosa or other            specificity of 98.9%
                                                                                                      haematic traces in small bowel   distinct pathological findings
                                                                                                      lumen                           Testing; 2,702 images containing blood,
                                                                                                                                      1,717 with normal mucosa or other distinct
                                                                                                                                      pathological findings

                              Muruganantham and  Active GI     2022          Retrospective India      Construct dual branch CNN model  Training and testing conducted on   CNN       No sensitivity and specificity
                                         [20]                                                                                                [111]
                              Balakrishnan       bleeding                                             with a novel lesion attention map   bleeding   and Kvasir-Capsule              could be found
                                                                                                                                            [112]
                                                                                                      estimator model                 dataset                                        Accuracy of 94.40% for bleeding
                                                                                                                                      Training: 3,430 images                         detection on bleeding dataset
                                                                                                                                      Testing: 1,470 images                          Accuracy of 93.18% for ulcer,
                                                                                                                                                                                     93.89% for bleeding, 97.73% for
                                                                                                                                                                                     polyp, 96.67% for normal on
                                                                                                                                                                                     Kvasir-Capsule dataset

                              *                                                                                                                                                      [13,14]
                              An inconsistency was noted in publications from the same group. Jia et al.’s 2017 later work referenced the prior 2016 work but reports an inconsistent  recall/sensitivity  . AI: Artificial intelligence; GI:
                              gastrointestinal; SVM: support vector machine; CAD: computer aided design; MLP: multilayer perceptron; RGB: red, green blue; HSI: hue, saturation, intensity; BP: back propagation; PNN: probabilistic neural network;
                              WCE: wireless capsule endoscopy; KNN: K-nearest neighbour; CNN: convolutional neural network; ROI: region of interest; SPCH: superpixel-colour histogram; KID: koulaouzidis-iakovidis database.
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