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Page 4 of 23                                                                               George et al. Mini-invasive Surg 2024;8:4  https://dx.doi.org/10.20517/2574-1225.2023.102


                              Table 1. Table of AI applications in capsule endoscopy for active GI bleeding

                                                               Year of       Study        Study
                              Ref.               Application                                          Aim                             Training/Validation dataset          AI type   Results
                                                               publication   design       location
                                           [3]
                              Giritharan et al.  Active GI     2008          Retrospective America    Develop a method to re-balance   550 bleeding images                 SVM       Sensitivity of 80%
                                                 bleeding                                             training images
                                        [8]
                              Li and Meng        Active GI     2009          Retrospective China      Develop new CAD system utilising  Training: 1,800 bleeding patches and   MLP   Sensitivity of 92.6%,
                                                 bleeding                                             colour-texture features and neural  1,800 normal patches                       specificity of 91%
                                                                                                      network classifier              Testing: 1,800 bleeding patches and
                                                                                                                                      1,800 normal patches
                                      [4]
                              Pan et al.         Active GI     2009          Retrospective China      Use colour-texture features in RGB  Training: 10,000 pixels          BP neural  Sensitivity of 93%,
                                                 bleeding                                             and HSI as input in BP neural   Testing: 3,172 bleeding images and   network   specificity of 96%
                                                                                                      network                         11,458 non-bleeding images
                                      [7]
                              Pan et al.         Active GI     2011          Retrospective China      Use colour-texture features in RGB  Training: 50,000 pairs           PNN       Sensitivity of 93.1%,
                                                 bleeding                                             and HSI as input in PNN         Testing: 3,172 bleeding images and             specificity of 85.8%
                                                                                                                                      11,458 non-bleeding images
                                        [5]
                              Ghosh et al.       Active GI     2014          Retrospective Bangladesh  Use RGB colour-texture feature in   Training: 50 bleeding images and   SVM    Sensitivity of 93.00%,
                                                 bleeding                                             SVM                             200 non-bleeding images                        specificity of 94.88%
                                                                                                                                      Testing: 400 bleeding and
                                                                                                                                      1,600 non-bleeding images
                                              [6]
                              Hassan and Haque   Active GI     2015          Retrospective Bangladesh  Utilise characteristic patterns in   Training: 600 bleeding and     SVM       Sensitivity of 99.41%,
                                                 bleeding                                             frequency spectrum of WCE       600 non-bleeding frames                        specificity of 98.95%
                                                                                                      images                          Testing: 860 bleeding and
                                                                                                                                      860 non-bleeding images
                                       [9]
                              Yuan et al.        Active GI     2016          Retrospective China      Construct two-fold system for   Testing: 400 bleeding frames and     SVM and  Sensitivity of 92%,
                                                 bleeding                                             detection and localisation of   2,000 normal frames                  KNN       specificity of 96.5%
                                                                                                      bleeding regions
                                         [13]                                                                                                                                                          *
                              Jia and Meng       Active GI     2016          Retrospective China      Develop deep neural network that  Training: 2,050 bleeding and       CNN       Sensitivity of 99.20%
                                                 bleeding                                             can automatically and           6,150 non-bleeding images
                                                                                                      hierarchically learn high-level   Testing: 800 bleeding,
                                                                                                      features                        1,000 non-bleeding
                                         [14]
                              Jia and Meng       Active GI     2017          Retrospective China      Combine handcrafted and CNN     Training: 200 bleeding frames and    CNN       Sensitivity of 91%
                                                 bleeding                                             features for characterisation   800 normal frames
                                                                                                                                      Testing: 100 bleeding frames and
                                                                                                                                      400 normal frames
                                        [21]
                              Kundu et al.       Active GI     2018          Retrospective Bangladesh  Detecting bleeding images based   Testing: 5 videos, with 100 image   KNN     Sensitivity of 85.7%,
                                                 bleeding                                             on precise ROI detection in     frames each                                    specificity of 69.6%
                                                                                                      normalised RGB colour plane
                                        [10]
                              Ghosh et al.       Active GI     2018          Retrospective Bangladesh/  Utilising cluster-based statistical   Testing: 5 WCE videos        SVM       Sensitivity of 96.5%,
                                                 bleeding                                 Canada      feature extraction for global feature                                          specificity of 94.6%
                                                                                                      vector construction
                                      [22]
                              Xing et al.        Active GI     2018          Retrospective China      Using SPCH feature based on the   Training: 340 bleeding frames and   KNN      Sensitivity of 98.5%,
                                                 bleeding                                             principal colour spectrum to    340 normal ones                                specificity of 99.5%
                                                                                                      discriminate bleeding frames    Testing: 160 bleeding frames and
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