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Special Issue
Immunotherapy as a new hope against solid tumors
Guest Editor:
Dr. Francesco Perri
Medical Oncology Unit, POC
SS Annunziata, Taranto, Italy.
Email:
francesco.perri80@alice.it;
francescoperri508@gmail.com
Special Issue Introduction
The immune system is able to defend us against both pathogens and cancer.
Immune response against cancer cells is very complex, and it can be divided
into three phases, such as: the innate immune response; the activation of
specic T-cells against cancer and the killing of tumour cells made by the above
mentioned T-cells.
On the basis of these ndings, it is easy to understand that strengthen the
immune response against tumour cells may be an incisive strategy of therapy.
Several immunotherapy approaches have been proposed over the years,
however all of them have a common characteristic: the possibility to obtain a
class of T-cytotoxic lymphocytes able to attack the tumor.
Immunotherapy strategies that have been developed over the years may be
briey divided in ve categories: 1) direct administration of immunogenic tumour
antigens; 2) providing DC pulsed with specic tumour antigens; 3) providing
specic T-Cells, pulsed with immunogenic tumour antigens; 4) administering
cytokines able to activate T-Cells against tumour cells, 5) modifying the
microenviromnent in which the T-Cells mature, removing all the stimuli able to
induce T-Cells anergy.
The history of immunotherapy starts with the administration of prototypes of
cancer vaccines, such as the Coley toxin and ends with the discover of the last
generation checkpoint inhibitors.
Aim of our special issue is to review the importance and the clinical applications
of several strategies of immunotherapy against solid tumors.
Benets
Rigorous mechanism in peer review: one manuscript must be reviewed by at
least two relevant experts. We will endeavour to ensure high standards for the
review process and subsequent publication by a team of efcient and
professional reviewers and scientic editors.
No publication fee: there would be absolutely no charge for publication.
Rapid publication: we will do our best to ensure that accepted papers will be
published rapidly with a high quality.
Open Access: As an author you will retain the copyright to your work. By
licensing your work under the Creative Commons Attribution License, articles
can be re-used and re-distributed without restriction, as long as the original
work is correctly cited.
Wide promotions: Published articles will be promoted at academic
conferences, through social networks for scientists and relevant indexing
services.
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