Page 58 - Read Online

Page 148 Shad. J Transl Genet Genom 2023;7:141-65 https://dx.doi.org/10.20517/jtgg.2023.11

Arranz et al., HTR2A G-1438A (rs6311) 274 Caucasian Dose range 125-600 At least 3 GAS Positive association between CLZ response and
[73]
1998 mg/day months G-1438/A-1438 genotype (0.002). and G-
1438/A allele (P = 0.004) in sample1 and
combined sample.1 and 2. Negative correlation
was reported with G/G genotype
Masellis et al., HTR2A His452Tyr (rs6314) 185 Caucasian, African NA At least 6 GAS HTR2A his452tyr allele and genotype negatively
[74]
1998 American, and Asians months associated with CLZ response (corrected P =
0.04 and P = 0.04, respectively

Arranz et al., HTR2A T102C (rs6313) 149 European Caucasian Dose range - 125-600 3 months GAS -C102/T102 associated with better CLZ response
[75]
1995 mg/day (59%) than T102/T102 (16%) and C102/C102
(25%) in Schizophrenia patients
Souza et al., HRT3A rs1062613 140 Caucasian and African NA At least 6 BPRS -HRT3A rs1062613 associated with CLZ response
[76]
2010 American months (adjusted P = 0.041).
-A-C-C haplotype of rs2276302-rs1062613-
rs1150226 was associated with better CLZ
response (adjusted P = 0.04)
Rajkumar et al., HTR3A rs1062613, 101 Indian Mean dose: 304.84 ± At least 12- BPRS -T allele of rs1062613 and G allele of rs2276302
[77]
2012 rs2276302 119.04 mg/day weeks associated with CLZ response (P = 0.02)
-Combined clinical predictors and HTR3A
markers explained 38 % variability in CLZ
response
Kohlrausch et al., SLC6A4 HTTLPR/rs25531 116 Brazilian (European Average dose = 540.91 At least 3 BPRS HTTLPR/rs25531 with SO/SO or SO/LO
[78]
2010 background) months genotypes associated with CLZ nonresponse (P =
0.01) and LO/LO with CLZ response (P = 0.04)
[79]
Yu et al., 1999 HTR6 267T 99 Chinese Mean dose: 271.6 mg/day At least 8 weeks BPRS HTR6 267T/T genotype had a better CLZ
for 267C/C, 287.5 mg/day response than T/C or C/C groups
for 267C/T, and 241.7
mg/day for 267T/T
Sodhi et al., HTR2C Cys23Ser (rs6318) 162 Caucasian Dose range = 125-600 At least 3 GAS Patients with one or more 5HT2C ser alleles were
[80]
1995 mg/day months clozapine responders (P = 0.005)
Combinatorial Genetic Assays to Predict Clozapine Response

Arranz et al., HTR2A 200 Caucasian NA NA GAS -Six polymorphisms 5-HT2A 102-T/C,
[81]
2000 -102-T/C His452Tyr, -1438-G/A, 5-HT2C _330-GT/244-
-1438-G/A CT, Cys23Ser, 5-HTTLPR, and H2 1018-G/A)
-His452Tyr showed the strongest association with CLZ
HTR2C response (P < 0·09) and PPV of 76·86% (P =
-330-GT/-244-CT 0·0001).
-Cys23Ser -Strongest correlations with 5-HT2A 102-T/C,
5HTLLPR and -1438-G/A,
-H2 -1018-G/A
Hwang et al., In Caucasians 232 Caucasians and African NA At least 6 BPRS In Caucasians, strongest gene interactions
[82]
2011 -DRD1 rs686 and DRD3 Americans months observed between DRD1 rs686 and DRD3 Ser9Gly
Ser9Gly (P = 0.048), followed by DRD2 TaqIB and DRD3
-DRD2 TaqIB and DRD3 rs2134655 (P = 0.037), and DRD2 TaqIA & DRD3
rs2134655 rs2134655 (P = 0.040) for BPRS change; & DRD1