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Page 340 Estévez-Arias et al. J Transl Genet Genom 2022;6:333-52 https://dx.doi.org/10.20517/jtgg.2022.04
Figure 1. Schematic summary of genes causing CMT hereditary neuropathy. Gene products are assigned either to the neuron body and
axon or to the myelinating Schwann cell (cross-sectional view in box). Proteins are classified according to their main functions or
pathways and their proposed pathomechanisms in CMT. The most commonly involved genes are indicated in bold. More information
about each gene and/or protein is available in Table 2 and Supplementary Table 1. ER: Endoplasmic reticulum. Illustration created with
BioRender (Available from: https://biorender.com/).
Figure 2. Most common CMT-associated genes and their proposed pathomechanisms. Subcellular localization and the main functions
of gene products are indicated. (A) Diagram showing a neuron soma. (B) A myelinating Schwann cell. Illustration created with
BioRender (Available from: https://biorender.com/).
