Page 47 - Read Online
P. 47
Plössl et al. J Transl Genet Genom 2022;6:46-62 https://dx.doi.org/10.20517/jtgg.2021.39 Page 60
Availability of data and materials
Not applicable.
Financial support and sponsorship
The FV3000 confocal microscope was funded by a grant (INST 89/506-1 FUGG, 91b GG) from the
Deutsche Forschungsgemeinschaft (DFG) to Weber BHF.
Conflicts of interest
All authors declared that there are no conflicts of interest.
Ethical approval and consent to participate
The culture and differentiation of hiPSC from human donor material were approved by the Ethics Review
Board of the University of Regensburg, Germany (reference no. 12-101-0241) and have been performed in
accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later
amendments. Informed consent was given by the probands participating in the study.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2022.
REFERENCES
1. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ 2004;82:844-
51. DOI PubMed PMC
2. Colijn JM, Buitendijk GHS, Prokofyeva E, et al; EYE-RISK consortium, European Eye Epidemiology (E3) consortium. Prevalence of
age-related macular degeneration in europe: the past and the future. Ophthalmology 2017;124:1753-63. DOI PubMed PMC
3. Chen Y, Bedell M, Zhang K. Age-related macular degeneration: genetic and environmental factors of disease. Mol Interv 2010;10:271-
81. DOI PubMed PMC
4. Dalvi S, Galloway CA, Winschel L, et al. Environmental stress impairs photoreceptor outer segment (POS) phagocytosis and
degradation and induces autofluorescent material accumulation in hiPSC-RPE cells. Cell Death Discov 2019;5:96. DOI PubMed
PMC
5. Fritsche LG, Igl W, Bailey JN, et al. A large genome-wide association study of age-related macular degeneration highlights
contributions of rare and common variants. Nat Genet 2016;48:134-43. DOI PubMed PMC
6. Sobrin L, Seddon JM. Nature and nurture- genes and environment- predict onset and progression of macular degeneration. Prog Retin
Eye Res 2014;40:1-15. DOI PubMed PMC
7. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration.
Surv Ophthalmol 2000;45:115-34. DOI PubMed
8. Cai X, McGinnis JF. Oxidative stress: the achilles' heel of neurodegenerative diseases of the retina. Front Biosci (Landmark Ed)
2012;17:1976-95. DOI PubMed
9. Lambros ML, Plafker SM. Oxidative stress and the Nrf2 anti-oxidant transcription factor in age-related macular degeneration. Adv Exp
Med Biol 2016;854:67-72. DOI PubMed PMC
10. Bird A. Role of retinal pigment epithelium in age-related macular disease: a systematic review. Br J Ophthalmol 2021;105:1469-74.
DOI PubMed
11. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005;85:845-81. DOI PubMed
12. Krohne TU, Kaemmerer E, Holz FG, Kopitz J. Lipid peroxidation products reduce lysosomal protease activities in human retinal
pigment epithelial cells via two different mechanisms of action. Exp Eye Res 2010;90:261-6. DOI PubMed
13. Jarrett SG, Boulton ME. Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med 2012;33:399-417.
DOI PubMed PMC
14. Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 2006;38:769-89. DOI PubMed
15. Sachdeva MM, Cano M, Handa JT. Nrf2 signaling is impaired in the aging RPE given an oxidative insult. Exp Eye Res 2014;119:111-
4. DOI PubMed PMC
16. Wang L, Kondo N, Cano M, et al. Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented
epithelial cells. Free Radic Biol Med 2014;70:155-66. DOI PubMed PMC
17. Oh YS, Jun HS. Effects of glucagon-like peptide-1 on oxidative stress and Nrf2 signaling. Int J Mol Sci 2017;19:26. DOI PubMed
PMC