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Comertpay et al. J Transl Genet Genom 2022;6:84-94 https://dx.doi.org/10.20517/jtgg.2021.44 Page 92

[40]
microenvironment . Moreover, the Indian Hedgehog signaling system has been linked to the development
[41]
of hepatocellular cancer in obese mice , and downregulation of Sonic Hedgehog signaling in the
[42]
hippocampus leads to neuronal death in mice fed a high-fat diet .
In conclusion, this unique approach provides a generic paradigm for mapping complex genetic networks
underlying human disease from gene expression data, and the understanding of the reciprocal interplay
between obesity and cancer elucidated can begin to affect clinical practice. Therefore, response to
conventional and targeted therapies is an essential issue to investigate in experimental and computational
studies. As with the development of personalized oncology approaches, there is a need to evaluate new
diagnostic and therapeutic strategies to understand the obesity and cancer interplay. In the present study, it
was represented that CCND1, GRIA2, IL6ST, MMP9, and PRKAR2B, as well as pathways associated with
these genes, may be molecular signatures in obese patients with breast cancer. These genes may be used for
risk analysis of the disease progression of obese patients with breast cancer. Further experimental studies
should be conducted and large sample studies should be carried out.

DECLARATIONS
Authors’ contributions
Conceptualization, data curation, formal analysis, investigation, methodology, visualization, and writing -
original draft: Comertpay B
Supervision, validation, writing review and editing: Gov E
All authors have read and agreed to the published version of the manuscript.

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2022.

REFERENCES
1. Mckinney SM, Sieniek M, Godbole V, et al. International evaluation of an AI system for breast cancer screening. Nature 2020;577:89-
94. DOI PubMed
2. World Cancer Report: Cancer Research for Cancer Prevention (PDF). Available from: https://shop.iarc.fr/products/world-cancer-
report-cancer-research-for-cancer-prevention-pdf [Last accessed on 7 Jan 2022].
3. McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ
2000;321:624-8. DOI PubMed PMC
4. Andò S, Gelsomino L, Panza S, et al. Obesity, leptin and breast cancer: epidemiological evidence and proposed mechanisms. Cancers
(Basel) 2019;11:62. DOI PubMed PMC
5. Afshin A, Forouzanfar MH, Reitsma MB, et al; GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195
countries over 25 years. N Engl J Med 2017;377:13-27. DOI PubMed PMC