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Oquendo et al. J Transl Genet Genom 2021;5:89-111 https://dx.doi.org/10.20517/jtgg.2021.04 Page 91
Figure 1. Timeline highlighting historical milestones in the understanding of SMZL. HPLL refers to the determinant factors in the
stratification model (haemoglobin, platelet count, high lactate dehydrogenase, and lymphadenopathy) and the three groups patients are
grouped in (A, B and C). NGS: Next generation sequencing; CBL-MZ: clonal B-cell lymphocytosis of marginal zone origin; MZ: marginal
zone; IGHV: immunoglobulin heavy chain variable region; WGS: whole genome sequencing; WES: whole exome sequencing; NF-κB:
nuclear factor kappa-light-chain-enhancer of activated B cells; LDH: lactate dehydrogenase; HCV: hepatitis C virus; WHO: World Health
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Organisation; SMZL: splenic marginal zone lymphoma. Additional references .
