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Donskov et al. J Transl Genet Genom 2021;5:136-62 https://dx.doi.org/10.20517/jtgg.2021.12 Page 15
Figure 5. Sex-biased expression of NTC genes. Mapped are NTC genes that are sex-differentially expressed in the developing human
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brain as reported by Shi et al. . Red indicates higher expression in females, while blue indicates higher expression in males. Common
and rare variants in NTC genes associated with particularly SZ and ASD are enriched in clusters with female-biased expression in the
anterior cingulate cortex (MFC) and orbital frontal cortex (OFC) and male-biased expression in striatum (STR) during prenatal
development. SZ MWAS risk genes cluster with genes expressed with female-biased MD (mediodorsal nucleus of thalamus) in
childhood. NTC: NR transcriptomic complex; SZ: schizophrenia; ASD: autism spectrum disorder.
PDs. We note that particularly the NR subset of the NTC is associated with affective disorders, whereas the
risk burden in NR coregulators is dominant in SZ and ASD. Interestingly, NR-encoding genes generally
peak in their expression postnatally, whereas NR coregulators - particularly those associated with ASD and
