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Page 348 Genvigir et al. J Transl Genet Genom 2020;4:320-55 I http://dx.doi.org/10.20517/jtgg.2020.37

Ref. [27] [22] [75]

Clinical outcomes No association of IMPDH2 variants with leukopenia or time to leukopenia IMPDH2 rs11706052 C allele was associated with reduced risk of AR No association of IMPDH2 variant with BMI change

Immunosuppressive regimen One-year follow-up Cyclosporine Tacrolimus One-year follow-up Five-year follow-up

MMF Tacrolimus Cyclosporine Sirolimus Corticosteroids MMF Sirolimus Corticosteroids MMF Cyclosporine Tacrolimus Corticosteroids

284 pediatric and young adult patients (USA) 145 adult patients (Brazil) 190 adult patients (Poland) AR: acute rejection; AUC: area under the concentration-time curve; BMI: body mass index; CMV cytomegalovirus; EC-MPS: enteric-coated mycophenolate sodium; MMF: mycophenolate mofetil; Study [13] . Likewise both rs2278294 and rs2278293 polymorphisms were not associated with leukopenia or anemia in adult patients from the Dominos Study within six mont
Population

Study design Retrospective (Case- control), multicenter Retrospective (Case-control) Prospective susceptibility to CMV and other infections in adult kidney recipients on MMF therapy from the Apomygre and FDCC studies [72] . from Poland, and found an association of the rs2278294 G allele with slower BMI gain over five years post-transplantation.

Allele frequency rs11706052 C: - rs4974081 G: - rs11706052 C: 11% rs11706052 C: 8% IMPDH2 rs11706052 A>G (c.819 + 10T>C) also known as 3757T>C [70] .

Variant
MPA: mycophenolyc acid

Gene found. IMPDH2