Page 45 - Read Online

Boshe et al. J Transl Genet Genom 2018;2:12. I https://doi.org/10.20517/jtgg.2018.18 Page 9 of 10

Financial support and sponsorship
None.

Conflicts of interest
The authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
This study was approved as exempt, #14-2303, by the institutional review board of the University of North
Carolina- Chapel Hill.

Consent for publication
Not applicable.

Copyright
© The Authors 2018.

REFERENCES
1. Chong JX, Buckingham KJ, Jhangiani SN, Boehm C, Sobreira N, Smith JD, Harrell TM, McMillin MJ, Wiszniewsk W, Gambin T, Ak-
demir ZHC, Doheny K, Scott AF, Avramopoulos D, Chakravarti A, Hoover-Fong J, Mathews D, Witmer PD, Ling H, Hetrick K, Watkins
L, Patterson KE, Reinier F, Blue E, Muzny D, Kircher M, Bilguvar K, López-Giráldez F, Sutton RV, Tabor HK, Leal SM, Gunel M, Mane
S, Gibbs RA, Boerwinkle E, Hamosh A, Shendure J, Lupski JR, Lifton RP, Valle D, Nickerson DA, Bamshad MJ; Centers for Mendelian
Genomics. The genetic basis of mendelian phenotypes: discoveries, challenges, and opportunities. Am J Hum Genet 2015;97:199-215.
2. Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ, Ledbetter DH, Maglott DR, Martin CL, Nussbaum RL, Plon SE,
Ramos EM, Sherry ST, Watson MS; ClinGen. ClinGen - The Clinical Genome Resource. N Engl J Med 2015;372:2235-42.
3. Transforming Genetic Medicine Initiative (TGMI) online resource. GEMSTAR. Available from: http://www.thetgmi.org//gemstar/. [Last ac-
cessed on 24 Jun 2018]
4. Genomics England PanelApp online resource. Long QT syndrome (Version 1.5). Available from: https://panelapp.genomicsengland.co.uk/
panels/76/. [Last accessed 24 Jun 2018]
5. Shah SR, Ki P. Long QT syndrome: a comprehensive review of the literature and current evidence. Curr Probl Cardiol 2018;18:30051-3.
6. Amin AS, Arthur AMW. Genetic screening in acquired long QT syndrome? Caution: proceed carefully. Eur Heart J 2016;37:1465-8.
7. Rohatgi RK, Sugrue A, Bos JM, Cannon BC, Asirvatham SJ, Moir C, Owen HJ, Bos KM, Kruisselbrink T, Ackerman MJ. Contemporary
outcomes in patients with LQTS. J Am Coll Cardiol 2017;70:453-62.
8. Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J, Hall WJ, Weitkamp L, Vincent GM, Garson A Jr., Robinson JL,
Benhorin J, Choi S. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 1991;84:1136-44.
9. Fernández-Falgueras A, Sarquella-Brugada G, Brugada J, Brugada R, Campuzano O. Cardiac channelopathies and sudden death: recent
clinical and genetic advances. Biology (Basel) 2017;6.pii:E7.
10. Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastan-
tuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M. The genetics
underlying acquired long QT syndrome: impact for genetic screening. Eur Heart J 2016;37:1456-64.
11. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt
A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C. Executive summary: HRS/EHRA/APHRS expert consensus statement on the
diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm 2013;10:e85-108.
12. Giudicessi JR, Wilde AAM, Ackerman MJ. The genetic architecture of long QT syndrome: a critical reappraisal. Trends Cardiovasc Med
2018; doi: 10.1016/j.tcm.2018.03.003.
13. Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Lar-
son EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson
H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoe-
maker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden
DM. Association of arrhythmia-related genetic variants with phenotypes documented in electronic medical records. JAMA 2016;315:47-57.
14. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirch-
hof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekvål TM, Spaulding C, Van Veldhuisen DJ. 2015 ESC guidelines
for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Rev Esp Cardiol (Eng Ed) 2016;
69:176.
15. Czosek RJ, Kaltman JR, Cassedy AE, Shah MJ, Vetter VL, Tanel RE, Wernovksy, G, Wray J, Marino BS. Quality of life of pediatric patients
with long QT syndrome. Am J Cardiol 2016;117:605-10.
16. Giuffre RM, Gupta S, Crawford SG, Leung AK. Fears and anxiety in children with long-QT syndrome compared to children with asthma. J
Natl Med Assoc 2008;100:420-4.