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A
B
C
Figure 2. JAK inhibitors: chemical structures for JAK inhibitors described in this review were created using MarvinSketch software
downloaded from ChemAxon (Budapest, Hungary) [115,171-183] . Food and Drug Administration (FDA)-approved JAK inhibitors that have
been tested clinically in solid tumors (A); JAK inhibitors that are not FDA approved but have been tested clinically in solid tumors (B);
JAK inhibitors that have only been tested in solid tumor preclinical models, and lestaurtinib, which has been tested clinically in solid
tumors for its activity against other targets (C). Structures for INCB047986 and INCB052793 are not publicly available and therefore
are not shown in this figure. *FDA approved for another indication; JAKs: Janus kinases
