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Zaichick et al. J Cancer Metastasis Treat 2019;5:48 Journal of Cancer
DOI: 10.20517/2394-4722.2019.07 Metastasis and Treatment

Original Article Open Access

Significance of trace element quantities in the
prostatic secretion of patients with benign prostatic

hyperplasia and prostate cancer

Vladimir Zaichick , Sofia Zaichick 2
1
1 Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk 249036, Russia.
2 Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Correspondence to: Prof. Vladimir Zaichick, Radionuclide Diagnostics Department, Medical Radiological Research Centre,
Korolyev St. 4, Obninsk 249036, Kaluga region, Russia. E-mail: vzaichick@gmail.com; vzaichik@outlook.com

How to cite this article: Zaichick V, Zaichick S. Significance of trace element quantities in the prostatic secretion of patients with
benign prostatic hyperplasia and prostate cancer. J Cancer Metastasis Treat 2019;5:48.
http://dx.doi.org/10.20517/2394-4722.2019.07

Received: 10 Jan 2019 First Decision: 18 Mar 2019 Revised: 11 Apr 2019 Accepted: 14 May 2019 Published: 13 Jun 2019
Science Editor: Gopal Kundu Copy Editor: Cai-Hong Wang Production Editor: Jing Yu

Abstract
Aim: Benign prostatic hyperplasia and prostate cancer is an internationally important health problem of the man,
particularly in developed countries. The aim of this exploratory study was to evaluate whether significant difference
in the levels of Zn and some other trace elements of prostatic fluid exist between the inflamed and malignantly
transformed prostate.

Methods: Prostatic fluid levels of Br, Fe, Rb, Sr, and Zn were prospectively evaluated in 52 patients with benign
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prostatic hyperplasia and 24 patients with prostate cancer. Measurements were performed using Cd radionuclide-
induced energy dispersive X-ray fluorescent microanalysis. Prostatic fluid samples were divided into two portions.
One was used for cytological study to exclude prostatitis, while the other was intended for trace element analysis.

Results: Mean values ± standard error of means for concentration (mg/L) of trace element in the prostatic fluid
of hyperplastic prostate were: Br 2.32 ± 0.30, Fe 11.5 ± 1.8, Rb 1.70 ± 0.23, Sr 1.41 ± 0.26, and Zn 488 ± 42. The
contents of Rb and Zn were significantly lower (approximately 3.2 and 7.7 times, respectively) in fluid of cancerous
prostate compared with those in fluid of hyperplastic prostate.

Conclusion: There are significant differences in trace element contents in the fluid of hyperplastic and malignantly
transformed prostate. The great decrease in levels of Rb and Zn in the fluid of cancerous prostate might demonstrate

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
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