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to be mentioned that authors not familiar with respiratory physiology often use “local O concentrations” by
2
mistake, although pO values have been measured in the original studies (for typical examples see Table 1
[2,3]
2
in the review by McKenna et al. ).
[1]
Considering Henry’s law (cO = α × pO ; α: oxygen solubility coefficient), McKenna et al. have communicated
[1]
2
2
questionable oxygenation data grounded on wrong/doubtful O solubility values for malignant and normal
2
tissues, which originally have been communicated for blood plasma, i.e., irrelevant data when heterogeneous
tissues such as prostate cancer are considered .
[8]
Oxygen solubility coefficients for heterogeneous tissues (e.g., for experimental tumors ) are significantly lower
[9]
than those for blood or blood plasma . Due to this misconception, the O concentration data of Table 1 in the
[10]
2
review by McKenna et al. are misleading/not correct and should, therefore, be removed from the table.
[1]
There is no need to present concentration data in this comprehensive review.
DECLARATIONS
Authors’ contributions
Vaupel P contributed solely to the paper.

Financial support and sponsorship
None.

Conflicts of interest
There are no conflicts of interest.

Patient consent
Not applicable.

Ethics approval
Not applicable.

Copyright
© The Author 2018.

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5. Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007;26:225-39.
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