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Sommariva                                                                                                                                                                                       Liver metastases and HIPEC

           peritoneal and liver metastases arise from different   REFERENCES
           ways of diffusion (loco-regional vs. haematogenous),
           probably reflecting a different cancer cell genetics or   1.   Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J,
           epigenetic alterations; as previously hypothesized,   Fontaumard E, Brachet A, Caillot JL, Faure JL, Porcheron J, Peix JL,
           a curative surgical resection for cancer is only      François Y, Vignal J, Gilly FN. Peritoneal carcinomatosis from non-
           cytoreductive surgery: surgery removes all detectable   gynecologic malignancies: results of the EVOCAPE 1 multicentric
           disease, but does not completely eradicate all tumor   2.   prospective study. Cancer 2000;88:358-63.
                                                                 Jayne DG, Fook S, Loi C, Seow-Choen F. Peritoneal carcinomatosis
           cells, since micro-metastases and circulating tumor   from colorectal cancer. Br J Surg 2002;89:1545-50.
           cells are present in the blood of colorectal cancer   3.   Chu DZ, Lang NP, Thompson C, Osteen PK, Westbrook KC. Peritoneal
           patients after radical primary tumor resection in one   carcinomatosis in nongynecologic malignancy. A prospective study of
           third of all patients [36] . The fact that survival after   prognostic factors. Cancer 1989;63:364-7.
           HIPEC is not lowered by concomitant liver resection   4.   Golfinopoulos V,  Salanti  G,  Pavlidis  N,  Ioannidis  JP.  Survival  and
                                                                 disease-progression  benefits  with  treatment  regimens  for  advanced
           adds an important piece of evidence supporting        colorectal cancer: a meta-analysis. Lancet Oncol 2007;8:898-911.
           this hypothesis that needs to be confirmed by more   5.   Chua TC,  Morris  DL,  Saxena A,  Esquivel  J,  Liauw W,  Doerfer  J,
           evidence.                                             Germer  CT,  Kerscher AG,  Pelz  JO.  Influence  of  modern  systemic
                                                                 therapies as adjunct to cytoreduction and perioperative intraperitoneal
                                                                 chemotherapy for patients with colorectal peritoneal carcinomatosis:
           CONCLUSION                                            a multicenter study. Ann Surg Oncol 2011;18:1560-7.
                                                              6.   Elias  D,  Lefevre  JH,  Chevalier  J,  Brouquet A,  Marchal  F,  Classe
           The reported data confirmed that CS-HIPEC allows      JM, Ferron G, Guilloit JM, Meeus P, Goéré D, Bonastre J. Complete
                                                                 cytoreductive  surgery plus intraperitoneal  chemohyperthermia  with
           the achievement of long-term survival in patients     oxaliplatin for peritoneal carcinomatosis of colorectal origin. J Clin
           usually referred for palliative systemic treatment.   Oncol 2009;27:681-5.
           Although an advantage of HIPEC in terms of         7.   Chua  TC,  Esquivel  J,  Pelz  JO,  Morris  DL.  Summary  of  current
           oncological outcome over systemic treatments          therapeutic options for peritoneal metastases from colorectal cancer. J
           has been not yet clearly proven, patients with no     Surg Oncol 2012;107:566-73.
           macroscopic residual disease, low peritoneal tumor   8.   Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier
                                                                 P, Bechstein WO, Primrose JN, Walpole ET, Finch-Jones M, Jaeck
           load and few liver metastases seem to be the          D, Mirza D, Parks RW, Collette L, Praet M, Bethe U, Van Cutsem
           best indicated for CS + HIPEC + LR. CS + HIPEC        E,  Scheithauer  W,  Gruenberger  T;  EORTC  Gastro-Intestinal  Tract
           associated with LR have mortality and morbidity       Cancer Group; Cancer Research UK; Arbeitsgruppe Lebermetastasen
           rates similar to that observed with CS + HIPEC        und-tumoren in der Chirurgischen  Arbeitsgemeinschaft  Onkologie
           alone, although major hepatectomy has rarely been     (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG);
           performed. For these reasons patients with peritoneal   Fédération  Francophone  de  Cancérologie  Digestive  (FFCD).
                                                                 Perioperative  chemotherapy  with FOLFOX4  and surgery versus
           carcinomatosis and liver metastases from colorectal   surgery alone for resectable liver metastases from colorectal cancer
           cancer should be referred to a tertiary center for    (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet
           selection of the more appropriate treatment, possibly   2008;371:1007-16.
           within clinical trials.                            9.   Yedibela S, Klein P, Feuchter K, Hoffmann M, Meyer T, Papadopoulos
                                                                 T,  Göhl  J,  Hohenberger  W.  Surgical  management  of  pulmonary
                                                                 metastases from colorectal cancer in 153 patients. Ann Surg Oncol
           DECLARATIONS                                          2006;13:1538-44.
                                                              10.  Sugarbaker PH, Jablonski KA. Prognostic features of 51 colorectal
           Authors’ contributions                                and 130 appendiceal cancer patients with peritoneal carcinomatosis
                                                                 treated  by cytoreductive  surgery and  intraperitoneal  chemotherapy.
           A. Sommariva contributed solely to the paper.         Ann Surg 1995;221:124-32.
                                                              11.  Carpizo DR, D’Angelica M. Liver resection for metastatic colorectal
           Financial support and sponsorship                     cancer  in  the  presence  of extrahepatic  disease.  Ann  Surg Oncol
           None.                                                 2009;16:2411-21.
                                                              12.  Elias D, Sideris L, Pocard M, Ouellet JF, Boige V, Lasser P, Pignon
           Conflicts of interest                                 JP, Ducreux M. Results of R0 resection for colorectal liver metastases
                                                                 associated with extrahepatic disease. Ann Surg Oncol 2004;11:274-
           There are no conflicts of interest.                   80.
                                                              13.  Elias D, Liberale G, Vernerey D, Pocard M, Ducreux M, Boige V,
           Patient consent                                       Malka  D,  Pignon  JP,  Lasser  P.  Hepatic  and  extrahepatic  colorectal
           The patient of the computed tomography scan of        metastases:  when  resectable,  their  localization  does  not  matter,
           Figure 1 gave his consent for publication.            but their total  number has a prognostic effect.  Ann Surg Oncol
                                                                 2005;12:900-9.
                                                              14.  Aoki  T,  Umekita  N,  Tanaka  S,  Noda  K,  Warabi  M,  Kitamura  M.
           Ethic approval                                        Prognostic value  of concomitant  resection  of extrahepatic  disease
           Not applicable.                                       in patients with liver metastases of colorectal  origin.  Surgery

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