Page 39 - Read Online

Topic: Brain tumor cell invasion and metastasis: anatomical,
biological and clinical considerations
Interdisciplinary management of central nervous system metastasis and
neoplastic meningitis: recent developments and future perspectives

Ghazaleh Tabatabai 1,13,14,17 , Marilin Koch 1,13,14 , Cristiana Roggia 1,13,14 , Juliane Ebert 1,13,14 , Claus Garbe 2,14 ,
Friedegund Meier 2,14,15 , Sara Brucker 3,14 , Eva Maria Grischke 3,14 , Diethelm Wallwiener 3,14 , Robert Möhle 4,14 ,
Lothar Kanz 4,14,17 , Walter Erich Aulitzky , Ulrike Ernemann 6,13,14 , Christian laFougere 7,13,14,17 ,
5
Konstantin Nikolaou 8,14 , Bernd Pichler 9,14,17 , Jens Schittenhelm 10,13,14 , Manuela Neumann 10,13,14 ,
Falko Fend 10,14 , Stefan Czemmel 1,14,16 , Sven Nahnsen 14,16 , Frank Paulsen 11,13,14 , Daniel Zips 11,13,14,17 ,
Maike van Lessen 1,12,13,14 , Hans-Otto Karnath 12,13,14 , Ulf Ziemann 1,13,14 , Hans-Georg Rammensee 17,18 ,
Constantin Roder 1,13,14 , Marco Skardelly 1,13,14 , Jürgen Bernd Honegger 1,13,14 , Marcos Tatagiba 1,13,14
1 Interdisciplinary Division of Neuro-Oncology, Departments of Vascular Neurology and Neurosurgery, University Hospital Tübingen, Hertie
Institute for Clinical Brain Research, Eberhard Karls University, 72076 Tübingen, Germany.
2 Division of Dermato-Oncology, Department of Dermatology, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
3 Department of Gynecology and Ostetrics, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
4 Department of Internal Medicine (II), University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
5 Department of Hematology and Oncology, Robert Bosch Hospital Stuttgart, Stuttgart, Germany, Comprehensive Cancer Center, Tübingen Stuttgart, Germany.
6 Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
7 Department of Nuclear Medicine, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
8 Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
9 Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
10 Department of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University , 72076 Tübingen, Germany.
11 Department of Radiation Oncology, University Hospital Tübingen, Eberhard Karls University, 72076 Tübingen, Germany.
12 Division of Neuropsychology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, 72076 Tübingen, Germany.
13 Center for CNS tumors, Comprehensive Cancer Center Tübingen Stuttgart, Germany.
14 Center for Personalized Medicine, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany.
15 Center for Dermato-Oncology, University Hospital Dresden, Germany.
16 Quantitative Biology Center (QBiC), Eberhard Karls University, Tübingen, Germany.
17 DKTK, DKFZ partner site Tübingen.
18 Department of Immunology, Eberhard Karls University Tübingen, Germany.
Correspondence to: Prof. Ghazaleh Tabatabai, Interdisciplinary Division of Neuro-Oncology, Departments of Vascular Neurology and
Neurosurgery, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University, 72076 Tübingen, Germany.
E-mail: ghazaleh.tabatabai@uni-tuebingen.de

A B S T R AC T
The incidence of metastatic disease in the central nervous system (CNS) is rising. According to current estimates, up to a third
of adult cancer patients will suffer from CNS metastasis. Clinical evidence-based data from prospective randomized trials are
rare, however, because CNS metastasis patients were often excluded from clinical trial participation. The management of CNS
metastasis patients is therefore rather ill-defined and an interdisciplinary challenge. Recent basic and translational science data
have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into
the CNS. This report reviews advances, challenges, and perspectives in this field.
Key words: Brain tumor; central nervous system metastases; interdisciplinary management

This is an open access article distributed under the terms of the Creative
Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows
others to remix, tweak, and build upon the work non-commercially, as long as
the author is credited and the new creations are licensed under the identical
terms.
For reprints contact: service@oaepublish.com
How to cite this article: Tabatabai G, Koch M, Roggia C, Ebert J,
Access this article online
Garbe C, Meier F, Brucker S, Grischke EM, Wallwiener D, Möhle
Quick Response Code: R, Kanz L, Auletzky WE, Ernemann U, La Fougere C, Nikolaou
Website: K, Pichler B, Schittenhelm J, Neumann M, Fend F, Czemmel S,
http://jcmtjournal.com Nahnsen S, Paulsen F, Zips D, Lessen MV, Karnath HO, Ziemann
U, Rammensee HG, Roder C, Skardelly M, Honegger JB, Tatagiba
M. Interdisciplinary management of CNS metastasis and neoplastic
meningitis:recentdevelopments and future perspectives. J Cancer
DOI: Metasta Treat 2016;2:163-75.
10.20517/2394-4722.2016.01
Received: 08-01-2016; Accepted: 09-03-2016.

©2016 Journal of Cancer Metastasis and Treatment ¦ Published by OAE Publishing Inc. 163