Page 28 - Read Online

importance of tyrosine 1062 for GDNF mediated neuronal A. Gene expression in papillary thyroid carcinoma reveals highly
differentiation and survival. J Biol Chem 2002;277:1991-9. consistent profiles. Proc Natl Acad Sci U S A 2001;98:15044-9.
111. Altomare DA, Testa JR. Perturbations of the AKT signaling pathway 127. Bettuzzi S, Davalli P, Astancolle S, Carani C, Madeo B, Tampieri A,
in human cancer. Oncogene 2005;24:7455-64. Corti A. Tumor progression is accompanied by significant changes in
112. Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield the levels of expression of polyamine metabolism regulatory genes
MD. Cellular function of phosphoinositide 3-kinases: implications and clusterin (sulfated glycoprotein 2) in human prostate cancer
for development, homeostasis, and cancer. Annu Rev Cell Dev Biol specimens. Cancer Res 2000;60:28-34.
2001;17:615-75. 128. Gobeil S, Zhu X, Doillon CJ, Green MR. A genome-wide shRNA
113. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese screen identifies GAS1 as a novel melanoma metastasis suppressor
CB, Cohen P. Characterization of a 3-phosphoinositide-dependent gene. Genes & Development 2008;22:2932-40.
protein kinase which phosphorylates and activates protein kinase 129. Rizzi F, Belloni L, Crafa P, Lazzaretti M, Remondini D, Ferretti
Balpha. Curr Biol 1997;7:261-9. S, Cortellini P, Corti A, Bettuzzi S. A novel gene signature for
114. Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks molecular diagnosis of human prostate cancer by RT-qPCR. PLoS
and cross-talks. Oncogene 2008;27:5527-41. One 2008;3:e3617.
115. López-Ramírez MA, Domínguez-Monzón G, Vergara P, Segovia 130. Wiesenhofer B, Stockhammer G, Kostron H, Maier H, Hinterhuber
J. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters H, Humpel C. Glial cell line-derived neurotrophic factor (GDNF) and
GDNF-mediated intracellular signaling. International Journal of its receptor (GFR-alpha 1) are strongly expressed in human gliomas.
Developmental Neuroscience 2008;26:497-503. Acta Neuropathol 2000;99:131-7.
116. Benítez JA, Arregui L, Vergara P, Segovia J. Targeted-simultaneous 131. Song H, Moon A. Glial cell-derived neurotrophic factor (GDNF) promotes
expression of Gas1 and p53 using a bicistronic adenoviral vector in low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38
gliomas. Cancer Gene Therapy 2007;14:836-46. MAPK signaling pathways. Neurosci Res 2006;56:29-38.
117. Zamorano A, Lamas M, Vergara P, Naranjo JR, Segovia J. 132. Ng WH, Wan GQ, Peng ZN, Too HP. Glial cell-line derived
Transcriptionally mediated gene targeting of gas1 to glioma cells neurotrophic factor (GDNF) family of ligands confer chemoresistance
elicits growth arrest and apoptosis. J Neurosci Res 2003;71:256-63. in a ligand-specific fashion in malignant gliomas. Journal of Clinical
118. Zamorano A, Mellström B, Vergara P, Naranjo JR, Segovia J. Glial- Neuroscience 2009;16:427-36.
specific retrovirally mediated gas1 gene expression induces glioma 133. Ku MC, Wolf SA, Respondek D, Matyash V, Pohlmann A, Waiczies
cell apoptosis and inhibits tumor growth in vivo. Neurobiology of S, Waiczies H, Niendorf T, Synowitz M, Glass R, Kettenmann H.
Disease 2004;15:483-91.
119. Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. GDNF mediates glioblastoma-induced microglia attraction but not
Proc Natl Acad Sci U S A 2001;98:10983-5. astrogliosis. Acta Neuropathol 2013;125:609-20.
120. Jiménez A, López-Ornelas A, Estudillo E, González-Mariscal L, 134. Widjaja A, Mix H, Golkel C, Flemming P, Egensperger R, Holstein
González RO, Segovia J. A soluble form of GAS1 inhibits tumor A, Rademaker J, Becker H, Hundt M, Wagner S, Manns MP.
growth and angiogenesis in a triple negative breast cancer model. Uncommon metastasis of a glioblastoma multiforme in liver and
Experimental Cell Research 2014;327:307-17. spleen. Digestion 2000;61:219-22.
121. Lu Z, Xu S. ERK1/2 MAP kinases in cell survival and apoptosis. 135. Russo MA, Paolillo M, Sanchez-Hernandez Y, Curti D, Ciusani E,
IUBMB Life 2006;58:621-31. Serra M, Colombo L, Schinelli S. A small-molecule RGD-integrin
122. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N. antagonist inhibits cell adhesion, cell migration and induces anoikis
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl- in glioblastoma cells. Int J Oncol 2013;42:83-92.
X(L), and Mcl-1 and promotes survival of human pancreatic cancer 136. Varner JA, Emerson DA, Juliano RL. Integrin alpha 5 beta 1
cells. J Cell Biochem 2000;79:355-69. expression negatively regulates cell growth: reversal by attachment
123. Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK- to fibronectin. Mol Biol Cell 1995;6:725-40.
induced cell death--apoptosis, autophagy and senescence. FEBS J 137. Zhang Y, Wang X, Han L, Zhou Y, Sun S. Green tea polyphenol
2010;277:2-21. EGCG reverse cisplatin resistance of A549/DDP cell line through
124. Wang H, Zhou X, Zhang Y, Zhu H, Zhao L, Fan L, Wang Y, Gang Y, candidate genes demethylation. Biomedicine & Pharmacotherapy
Wu K, Liu Z, Fan D. Growth arrest-specific gene 1 is downregulated and 2015;69:285-90.
inhibits tumor growth in gastric cancer. FEBS J 2012;279:3652-64. 138. Zhang YW, Zheng Y, Wang JZ, Lu XX, Wang Z, Chen LB, Guan
125. Sacilotto N, Castillo J, Riffo-Campos AL, Flores JM, Hibbitt O, XX, Tong JD. Integrated analysis of DNA methylation and mRNA
Wade-Martins R, Lopez C, Rodrigo MI, Franco L, Lopez-Rodas expression profiling reveals candidate genes associated with cisplatin
G. Growth Arrest Specific 1 (Gas1) Gene Overexpression in resistance in non-small cell lung cancer. Epigenetics 2014;9:896-909.
Liver Reduces the In Vivo Progression of Murine Hepatocellular 139. Zhao L, Pan Y, Gang Y, Wang H, Jin H, Tie J, Xia L, Zhang Y, He
Carcinoma and Partially Restores Gene Expression Levels. PLoS L, Yao L, Qiao T, Li T, Liu Z, Fan D. Identification of GAS1 as an
One 2015;10:e0132477. epirubicin resistance-related gene in human gastric cancer cells with
126. Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, a partially randomized small interfering RNA library. J Biol Chem
LiVolsi V, Frankel W, Kloos RT, Eng C, Pellegata NS, de la Chapelle 2009;284:26273-85.

Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ March 11, 2016 ¦ 111