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Page 14 of 15      D'Souza et al. J Cancer Metastasis Treat 2022;8:28  https://dx.doi.org/10.20517/2394-4722.2022.51

               65.       Alvarez-Vallina L, Russell SJ. Efficient discrimination between different densities of target antigen by tetracycline-regulatable T
                    bodies. Hum Gene Ther 1999;10:559-63.  DOI  PubMed
               66.       Watanabe K, Terakura S, Martens AC, et al. Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen
                    receptor-modified effector CD8+ T cells. J Immunol 2015;194:911-20.  DOI  PubMed
               67.       Chmielewski M, Hombach AA, Abken H. CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-
                    redirected T-cell attack. Gene Ther 2011;18:62-72.  DOI  PubMed
               68.       Frigault MJ, Lee J, Basil MC, et al. Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of
                    T cells. Cancer Immunol Res 2015;3:356-67.  DOI  PubMed  PMC
               69.       Viganò S, Utzschneider DT, Perreau M, Pantaleo G, Zehn D, Harari A. Functional avidity: a measure to predict the efficacy of
                    effector T cells? Clin Dev Immunol 2012;2012:153863.  DOI  PubMed  PMC
               70.       Zeh HJ, Perry-Lalley D, Dudley ME, Rosenberg SA, Yang JC. High avidity CTLs for two self-antigens demonstrate superior in vitro
                    and in vivo antitumor efficacy. J Immunol 1999;162:989-94.  PubMed
               71.       Walker AJ, Majzner RG, Zhang L, et al. Tumor antigen and receptor densities regulate efficacy of a chimeric antigen receptor
                    targeting anaplastic lymphoma kinase. Mol Ther 2017;25:2189-201.  DOI  PubMed  PMC
               72.       Arcangeli S, Rotiroti MC, Bardelli M, et al. Balance of Anti-CD123 chimeric antigen receptor binding affinity and density for the
                    targeting of acute myeloid leukemia. Mol Ther 2017;25:1933-45.  DOI  PubMed  PMC
               73.       Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the
                    administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010;18:843-51.  DOI  PubMed
                    PMC
               74.       Liu X, Jiang S, Fang C, et al. Affinity-Tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index
                    against tumors in mice. Cancer Res 2015;75:3596-607.  DOI  PubMed  PMC
               75.       Drent E, Themeli M, Poels R, et al. A rational strategy for reducing On-Target Off-Tumor effects of CD38-chimeric antigen receptors
                    by affinity optimization. Mol Ther 2017;25:1946-58.  DOI  PubMed  PMC
               76.       O’Rourke DM, Nasrallah MP, Desai A, et al. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen
                    loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med 2017;9:eaaa0984.  DOI  PubMed  PMC
               77.       Rafiq S, Brentjens RJ. Tumors evading CARs-the chase is on. Nat Med 2018;24:1492-3.  DOI  PubMed
               78.       Larson RC, Kann MC, Bailey SR, et al. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature
                    2022;604:563-70.  DOI
               79.       Hegde M, Mukherjee M, Grada Z, et al. Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape. J Clin
                    Invest 2016;126:3036-52.  DOI
               80.       Dao T, Pankov D, Scott A, et al. Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1. Nat
                    Biotechnol 2015;33:1079-86.  DOI  PubMed  PMC
               81.       Adusumilli PS, Zauderer MG, Rivière I, et al. A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with
                    malignant pleural disease, in combination with the Anti-PD-1 agent pembrolizumab. Cancer Discov 2021;11:2748-63.  DOI  PubMed
                    PMC
               82.       Brossart P. The Role of antigen spreading in the efficacy of immunotherapies. Clin Cancer Res 2020;26:4442-7.  DOI  PubMed
               83.       Beatty GL, Haas AR, Maus MV, et al. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor
                    activity in solid malignancies. Cancer Immunol Res 2014;2:112-20.  DOI  PubMed  PMC
               84.       Klampatsa A, Leibowitz MS, Sun J, Liousia M, Arguiri E, Albelda SM. Analysis and augmentation of the immunologic bystander
                    effects of car T cell therapy in a syngeneic mouse cancer model. Mol Ther Oncolytics 2020;18:360-71.  DOI  PubMed  PMC
               85.       Choe JH, Watchmaker PB, Simic MS, et al. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and
                    persistence in treating glioblastoma. Sci Transl Med 2021;13:eabe7378.  DOI  PubMed  PMC
               86.       Anurathapan U, Chan RC, Hindi HF, et al. Kinetics of tumor destruction by chimeric antigen receptor-modified T cells. Mol Ther
                    2014;22:623-33.  DOI  PubMed  PMC
               87.       Song DG, Ye Q, Poussin M, Chacon JA, Figini M, Powell DJ. Effective adoptive immunotherapy of triple-negative breast cancer by
                    folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level. J Hematol Oncol 2016;9:56.  DOI
                    PubMed  PMC
               88.       Smith TT, Moffett HF, Stephan SB, et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate
                    heterogeneous tumors. J Clin Invest 2017;127:2176-91.  DOI  PubMed  PMC
               89.       Chen SH, Hung WC, Wang P, Paul C, Konstantopoulos K. Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell
                    motility and invasion via MMP-7 activation. Sci Rep 2013;3:1870.  DOI  PubMed  PMC
               90.       Zhang L, Yu Z, Muranski P, et al. Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly
                    enhances tumor treatment efficacy. Gene Ther 2013;20:575-80.  DOI  PubMed  PMC
               91.       Cherkassky L, Morello A, Villena-Vargas J, et al. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-
                    mediated inhibition. J Clin Invest 2016;126:3130-44.  DOI  PubMed  PMC
               92.       Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target
                    immunotherapy responses. Sci Transl Med 2013;5:215ra172.  DOI  PubMed  PMC
               93.       Rodgers DT, Mazagova M, Hampton EN, et al. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.
                    Proc Natl Acad Sci USA 2016;113:E459-68.  DOI  PubMed  PMC
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