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Vogelstein B, Velculescu VE, Kinzler KW. Core signaling independent effect of twist and snail in promoting metastasis
pathways in human pancreatic cancers revealed by global of hepatocellular carcinoma. Hepatology 2009;50:1464-74.
genomic analyses. Science 2008;321:1801-6. 66. Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY,
54. Meidhof S, Brabletz S, Lehmann W, Preca BT, Mock K, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW, Yang MH.
Ruh M, Schuler J, Berthold M, Weber A, Burk U, Lubbert M, MicroRNA-146a directs the symmetric division of Snail-dominant
Puhr M, Culig Z, Wellner U, Keck T, Bronsert P, Kusters S, colorectal cancer stem cells. Nat Cell Biol 2014;16:268-80.
Hopt UT, Stemmler MP, Brabletz T. ZEB1-associated drug 67. Fan LC, Shiau CW, Tai WT, Hung MH, Chu PY, Hsieh FS,
resistance in cancer cells is reversed by the class I HDAC Lin H, Yu HC, Chen KF. SHP-1 is a negative regulator of
inhibitor mocetinostat. EMBO Mol Med 2015;7:831-47. epithelial-mesenchymal transition in hepatocellular carcinoma.
55. Friess H, Yamanaka Y, Buchler M, Ebert M, Beger HG, Oncogene 2015; doi: 10.1038/onc.2015.223.
Gold LI, Korc M. Enhanced expression of transforming 68. Xia L, Huang W, Tian D, Zhu H, Qi X, Chen Z, Zhang Y,
growth factor beta isoforms in pancreatic cancer correlates Hu H, Fan D, Nie Y, Wu K. Overexpression of forkhead box
with decreased survival. Gastroenterology 1993;105:1846-56. C1 promotes tumor metastasis and indicates poor prognosis in
56. Gore AJ, Deitz SL, Palam LR, Craven KE, Korc M. hepatocellular carcinoma. Hepatology 2013;57:610-24.
Pancreatic cancer-associated retinoblastoma 1 dysfunction 69. Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B,
enables TGF-beta to promote proliferation. J Clin Invest Wang W, Li QW, Wang J, Hou ZY, Fang JY, Yeh ET, Yang J,
2014;124:338-52. Yi J. De-SUMOylation of FOXC2 by SENP3 promotes the
57. Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, epithelial-mesenchymal transition in gastric cancer cells.
Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Oncotarget 2014;5:7093-104.
Stiewe T, Gaedcke J, Mernberger M, Crawford HC, 70. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X,
Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling
Hebrok M, Neesse A, Koenig A, Ellenrieder V. Antithetical pathway promotes pancreatic cancer invasion and metastasis.
NFATc1-Sox2 and p53-miR200 signaling networks govern Cancer Res 2012;72:655-65.
pancreatic cancer cell plasticity. EMBO J 2015;34:517-30. 71. Huang C, Xie D, Cui J, Li Q, Gao Y, Xie K. FOXM1c
58. Logsdon CD, Simeone DM, Binkley C, Arumugam T, promotes pancreatic cancer epithelial-to-mesenchymal
Greenson JK, Giordano TJ, Misek DE, Kuick R, Hanash S. transition and metastasis via upregulation of expression of
Molecular profi ling of pancreatic adenocarcinoma and chronic the urokinase plasminogen activator system. Clin Cancer Res
pancreatitis identifi es multiple genes differentially regulated in 2014;20:1477-88.
pancreatic cancer. Cancer Res 2003;63:2649-57. 72. Xia L, Huang W, Tian D, Zhang L, Qi X, Chen Z, Shang X,
59. Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Nie Y, Wu K. Forkhead box Q1 promotes hepatocellular
Zhang Y, Lefl ein J, Waghray M, Owens S, Wilkinson JE, carcinoma metastasis by transactivating ZEB2 and VersicanV1
Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, expression. Hepatology 2014;59:958-73.
Simeone DM. ATDC induces an invasive switch in 73. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H,
KRAS-induced pancreatic tumorigenesis. Genes Dev Qin Y, Zeng M, Guan XY, Li Y. MicroRNA-9 promotes tumor
2015;29:171-83. metastasis via repressing E-cadherin in esophageal squamous
60. Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, cell carcinoma. Oncotarget 2014;5:11669-80.
McAllister F, Reichert M, Beatty GL, Rustgi AK, 74. Lin YH, Wu MH, Liao CJ, Huang YH, Chi HC, Wu SM,
Vonderheide RH, Leach SD, Stanger BZ. EMT and Chen CY, Tseng YH, Tsai CY, Chung IH, Tsai MM,
dissemination precede pancreatic tumor formation. Cell Chen CY, Lin TP, Yeh YH, Chen WJ, Lin KH. Repression of
2012;148:349-61. microRNA-130b by thyroid hormone enhances cell motility.
61. Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, J Hepatol 2015;62:1328-40.
Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, 75. Zhang JP, Zeng C, Xu L, Gong J, Fang JH, Zhuang SM.
Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, MicroRNA-148a suppresses the epithelial-mesenchymal
Ramaswamy S, Toner M, Haber DA, Maheswaran S. transition and metastasis of hepatoma cells by targeting
Circulating breast tumor cells exhibit dynamic changes Met/Snail signaling. Oncogene 2014;33:4069-76.
in epithelial and mesenchymal composition. Science 76. Izumchenko E, Chang X, Michailidi C, Kagohara L, Ravi R,
2013;339:580-4. Paz K, Brait M, Hoque MO, Ling S, Bedi A, Sidransky D.
62. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal The TGFbeta-miR200-MIG6 pathway orchestrates the
transition. J Clin Invest 2009;119:1420-8. EMT-associated kinase switch that induces resistance to EGFR
63. Kahlert C, Lahes S, Radhakrishnan P, Dutta S, Mogler C, inhibitors. Cancer Res 2014;74:3995-4005.
Herpel E, Brand K, Steinert G, Schneider M, Mollenhauer M, 77. Ma J, Fang B, Zeng F, Ma C, Pang H, Cheng L, Shi Y, Wang H,
Reissfelder C, Klupp F, Fritzmann J, Wunder C, Benner A, Yin B, Xia J, Wang Z. Down-regulation of miR-223 reverses
Kloor M, Huth C, Contin P, Ulrich A, Koch M, Weitz J. epithelial-mesenchymal transition in gemcitabine-resistant
Overexpression of ZEB2 at the invasion front of colorectal pancreatic cancer cells. Oncotarget 2015;6:1740-9.
cancer is an independent prognostic marker and regulates 78. Huang N, Wu Z, Lin L, Zhou M, Wang L, Ma H, Xia J, Bin J,
tumor invasion in vitro. Clin Cancer Res 2011;17:7654-63. Liao Y, Liao W. MiR-338-3p inhibits epithelial-mesenchymal
64. Zeng S, Xiao YF, Tang B, Hu CJ, Xie R, Yang SM, transition in gastric cancer cells by targeting ZEB2 and
Li BS. Long noncoding RNA in digestive tract cancers: MACC1/Met/Akt signaling. Oncotarget 2015;6:15222-34.
function, mechanism, and potential biomarker. Oncologist 79. Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T,
2015;20:898-906. Harada K, Inazawa J, Kozaki K. miR-655 Is an
65. Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, EMT-suppressive microRNA targeting ZEB1 and TGFBR2.
Chou TY, Peng WL, Wu JC. Comprehensive analysis of the PLoS One 2013;8:e62757.

Journal of Cancer Metastasis and Treatment ¦ Volume 1 ¦ Issue 3 ¦ October 15, 2015 ¦ 189