Page 82 - Read Online
P. 82
Page 8 of 10 Grynkiewicz. J Cancer Metastasis Treat 2020;6:48 I http://dx.doi.org/10.20517/2394-4722.2020.112
pharmaceutical ingredients, by the application of a suitable nanosuspension. This new pre-formulation
solution is likely to revive some older clinical trial projects.
DECLARATIONS
Authors’ contributions
The author contributed solely to the article.
Availability of data and materials
Not applicable.
Financial support and sponsorship
None.
Conflicts of interest
The author declared that there are no conflicts of interest.
Ethical approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Copyright
© The Author(s) 2020.
REFERENCES
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA A Cancer J Clin 2018;69:7-34.
2. Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and
methods. Int J Cancer 2019;144:1941-53.
3. Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA) - General
Subjects 2013;1830:3670-95.
4. Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 2015;79:629-61.
5. Kaur V, Kumar M, Kumar A, Kaur K, Dhillon VS, Kaur S. Pharmacotherapeutic potential of phytochemicals: implications in cancer
chemoprevention and future perspectives. Biomed Pharmacother 2018;97:564-86.
6. Sharifi-Rad J, Ozleyen A, Boyunegmez Tumer T, et al. Natural products and synthetic analogs as a source of antitumor drugs.
Biomolecules 2019;9:679.
7. Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites 2012;2:303-36.
8. Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug
Discov 2015;14:111-29.
9. Ertl P, Schuhmann T. Cheminformatics analysis of natural product scaffolds: comparison of scaffolds produced by animals, plants, fungi
and bacteria. Mol Inform 2020;39:2000017.
10. Chen Y, Kirchmair J. Cheminformatics in natural product-based drug discovery. Mol Inform 2020:2000171.
11. Chen Y, Garcia de Lomana M, Friedrich NO, Kirchmair J. Characterization of the chemical space of known and readily obtainable natural
products. J Chem Inf Model 2018;58:1518-32.
12. Ntie-kang F, Nyongbela KD, Ayimele GA, Shekfeh S. “Drug-likeness” properties of natural compounds. Phys Sci Rev 2019;4.
13. Saldívar-gonzález FI, Pilón-jiménez BA, Medina-franco JL. Chemical space of naturally occurring compounds. Phys Sci Rev 2019;4.
14. Luo Y, Cobb RE, Zhao H. Recent advances in natural product discovery. Curr Opin Biotechnol 2014;30:230-7.
15. Lagunin AA, Goel RK, Gawande DY, et al. Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants
beyond their traditional use: a critical review. Nat Prod Rep 2014;31:1585-611.
16. Biasutto L, Mattarei A, Sassi N, et al. Improving the efficacy of plant polyphenols. Anticancer Agents Med Chem 2014;14:1332-42.
17. Grynkiewicz G, Szeja W, Krzeczyński P, Rusin A. Hexenoses in design of glycoconjugates - from chemistry to function biological
activity of genistein derivatives. Chem Biol Interface 2014;4:301-20.
18. Blakemore DC, Castro L, Churcher I, et al. Organic synthesis provides opportunities to transform drug discovery. Nature Chem
2018;10:383-94.