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Figure 2. Representative structures of natural isoflavones
century), which surfaced as an antidiabetic drug candidate, featuring effective inhibition of GLUT family
D-glucose transporters. Phlorizin turned out to be metabolically unstable, because susceptibility to
hydrolases; this ultimately led to the synthesis of C-glycosyl analogs, which turned into a new generation of
antidiabetics, started by the launch of dapagliflozin in 2012 [44-46] .
ISOFLAVONE ESTROGENS AND FOOD CONNECTION
One immediate reflection on the massive amount of research accumulated in recent decades on flavonoid
biological activity, is that of the large discrepancy in adopted quality standards, which even became a
subject of separate study [47,48] . Strict adherence to accuracy in measurement and good laboratory practices
