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DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the study and performed data analysis and
interpretation: D’Angelo F, Rampini A, Cardella S
Performed data acquisition: Rampini A, Cardella S
Performed administrative, technical, and material support: Nigri G, Valabrega S
Data review: Antonlino L, Aurello P, Ramacciato G

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Written informed consent for publication for images used in Figures 1-3 was obtained.

Copyright
© The Author(s) 2019.

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