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DECLARATIONS
Acknowledgments
I thank Drs. Luis de Lecea and Natalie Nevárez for providing critical critiques during the preparation of this
manuscript. I thank Dr. Peter Dong for making the illustrations featured in this manuscript. This review was
made possible thanks to a BRAIN Initiative NIMH F32MH115431. All efforts were made to include relevant
research, failure to do so is the sole responsibility of the author.

Authors’ contributions
Borniger JC contributed solely to this study.

Availability of data and materials
Not applicable.

Financial support and sponsorship
This study was supported by NIMH BRAIN Initiative (F32 MH115431).

Conflicts of interest
The author declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Bachmann J, Heiligensetzer M, Krakowski-Roosen H, Büchler MW, Friess H, et al. Cachexia worsens prognosis in patients with resectable
pancreatic cancer. J Gastrointest Surg 2008;12:1193.
2. Cash E, Sephton SE, Chagpar AB, Spiegel D, Rebholz WN, et al. Circadian disruption and biomarkers of tumor progression in breast cancer
patients awaiting surgery. Brain Behav Immun 2015;48:102-14.
3. Palesh O, Aldridge-Gerry A, Zeitzer JM, Koopman C, Neri E, et al. Actigraphy-measured sleep disruption as a predictor of survival among
women with advanced breast cancer. Sleep 2014;37:837-42.
4. Sephton SE, Sapolsky RM, Kraemer HC, Spiegel D. Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst
2000;92:994-1000.
5. Zhi J, Khozin S, Kuk D, Torres AZ, Sorg R, et al. Association of baseline body mass index (BMI) with overall survival (OS) in patients (pts)
with metastatic non-small cell lung cancer (mNSCLC) treated with nivolumab (N) and pembrolizumab (P). J Clin Oncol 2018;36:6553-3.
6. Borniger JC, Walker Ii WH, Surbhi, Emmer KM, Zhang N, et al. A role for hypocretin/orexin in metabolic and sleep abnormalities in a
mouse model of non-metastatic breast cancer. Cell Metab 2018;28:118-29.e5.
7. Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, et al. Functional polarization of tumour-associated macrophages by tumour-
derived lactic acid. Nature 2014;513:559-63.
8. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99.
9. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
10. Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, et al. Lung adenocarcinoma distally rewires hepatic circadian
homeostasis. Cell 2016;165:896-909.
11. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, et al. The influence of bio-behavioural factors on tumour biology:
pathways and mechanisms. Nat Rev Cancer 2006;6:240-8.
12. Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model
of ovarian carcinoma. Nat Med 2006;12:939-44.
13. Hakim F, Wang Y, Zhang SX, Zheng J, Yolcu ES, et al. Fragmented sleep accelerates tumor growth and progression through recruitment of
tumor-associated macrophages and TLR4 signaling. Cancer Res 2014;74:1329-37.
14. Evans JMM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ
2005;330:1304-5.