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DECLARATIONS
Acknowledgments
The authors would like to give special thanks to Alan Elder and Chloe Young for their critical contributions to
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the editing process and PA Masso-Welch for providing the raw data from published studies for Figure 1.

Authors’ contributions
Conception and design: Wallace TR, Tarullo SE, Lyons TR
Drew figures: Tarullo SE, Lyons TR
Manuscript writing/editing: Wallace TR, Tarullo SE, Crump LS, Lyons TR
Read and approved the final manuscript: Wallace TR, Tarullo SE, Crump LS, Lyons TR

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by American Cancer Society (RSG-16-171-010CSM); National Cancer Institute
(R01 CA211696-01A1); National Cancer Institute (R01 CA211696-02S1); and National Cancer Institute (F31
CA236140).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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