Page 90 - Read Online

Page 18 of 20 Ho et al. J Cancer Metastasis Treat 2019;5:70 I http://dx.doi.org/10.20517/2394-4722.2019.25

103. Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, et al. Protein aggregates are recruited to aggresome by histone deacetylase 6
via unanchored ubiquitin C termini. J Biol Chem 2012;287:2317-27.
104. Banreti A, Sass M, Graba Y. The emerging role of acetylation in the regulation of autophagy. Autophagy 2013;9:819-29.
105. Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective
quality-control autophagy. EMBO J 2010;29:969-80.
106. Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming
proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A 2016;113:13162-7.
107. Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, et al. Small-molecule inhibition of proteasome and aggresome function
induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A 2005;102:8567-72.
108. Santo L, Cirstea DD, Eda H, Nemani N, Arastu-Kapur S, et al. Inhibition of autophagy by ACY-1215, a selective HDAC6 inhibitor
accelerates carfilzomib-induced cell death in multiple myeloma. Blood 2013;122:4431.
109. Huang FI, Wu YW, Sung TY, Liou JP, Lin MH, et al. MPT0G413, a novel HDAC6-selective inhibitor, and Bortezomib synergistically
exert anti-tumor activity in multiple myeloma cells. Front Oncol 2019;9:249.
110. Bayraktar UD, Bashir Q, Qazilbash M, Champlin RE, Ciurea SO. Fifty years of melphalan use in hematopoietic stem cell
transplantation. Biol Blood Marrow Transplant 2013;19:344-56.
111. Pan Y, Gao Y, Chen L, Gao G, Dong H, et al. Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-
damaging chemotherapy. Clin Cancer Res 2011;17:3248-58.
112. Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol 2010;190:881-92.
113. Guo X, He D, Zhang E, Chen J, Chen Q, et al. HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and
DNA damage repair. J Exp Clin Cancer Res 2018;37:205.
114. Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, et al. Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Nature Communications 2019;10:1486.
115. Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol 2013;31:51-72.
116. Yamazaki T, Hannani D, Poirier-Colame V, Ladoire S, Locher C, et al. Defective immunogenic cell death of HMGB1-deficient tumors:
compensatory therapy with TLR4 agonists. Cell Death Differ 2013;21:69.
117. Joubert PE, Albert ML. Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor
cell. Front Immunol 2012;3:61.
118. Niewerth D, Jansen G, Assaraf YG, Zweegman S, Kaspers GJ, et al. Molecular basis of resistance to proteasome inhibitors in
hematological malignancies. Drug Resist Updat 2015;18:18-35.
119. Orlowski RZ, Kuhn DJ. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 2008;14:1649-57.
120. McConkey DJ, Zhu K. Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 2008;11:164-79.
121. Yong K, Gonzalez-McQuire S, Szabo Z, Schoen P, Hajek R. The start of a new wave: developments in proteasome inhibition in
multiple myeloma. Eur J Haematol 2018; doi: 10.1111/ejh.13071.
122. Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, et al. The proteasome load versus capacity balance determines apoptotic sensitivity
of multiple myeloma cells to proteasome inhibition. Blood 2009;113:3040-9.
123. Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, et al. Combined treatment with bortezomib plus bafilomycin A1 enhances
the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-
lysosome and ER stress. Int J Oncol 2011;38:643-54.
124. Qiao L, Zhang J. Inhibition of lysosomal functions reduces proteasomal activity. Neurosci Lett 2009;456:15-9.
125. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, et al. HDAC6 rescues neurodegeneration and provides an essential link between
autophagy and the UPS. Nature 2007;447:859-63.
126. Wu WK, Cho CH, Lee CW, Wu YC, Yu L, et al. Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of
proteasome inhibitor in gastric cancer cells. Autophagy 2010;6:228-38.
127. Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, et al. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-
induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 2007;14:230-9.
128. Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, et al. Linking of autophagy to ubiquitin-proteasome system is important for the
regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 2007;171:513-24.
129. Lu Y, Wang Y, Xu H, Shi C, Jin F, et al. Profilin 1 induces drug resistance through Beclin1 complex-mediated autophagy in multiple
myeloma. Cancer Sci 2018;109:2706-16.
130. Wang G, Zhou P, Chen X, Zhao L, Tan J, et al. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple
myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis. Cancer Biol Ther 2017;18:584-95.
131. Jagannathan S, Abdel-Malek MA, Malek E, Vad N, Latif T, et al. Pharmacologic screens reveal metformin that suppresses GRP78-
dependent autophagy to enhance the anti-myeloma effect of bortezomib. Leukemia 2015;29:2184-91.
132. Wang Y, Xu W, Yan Z, Zhao W, Mi J, et al. Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting
the AMPK/mTORC1 and mTORC2 pathways. J Exp Clin Cancer Res 2018;37:63.
133. Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, et al. Metformin triggers apoptosis in PEL cells and alters
bortezomib-induced unfolded protein response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation. Cell Signal
2017;40:239-47.
134. Chen Q, Xie W, Kuhn DJ, Voorhees PM, Lopez-Girona A, et al. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-
mediated cell-cycle arrest and activation of autophagy. Blood 2008;111:4690-9.