Page 66 - Read Online
P. 66
Eng et al. J Cancer Metastasis Treat 2019;5:69 I http://dx.doi.org/10.20517/2394-4722.2019.021 Page 7 of 13
Figure 2. MiRNA inhibition of autophagy during secondary tumor formation. In the colonization process, autophagy is inhibited either
by upregulation of anti-autophagy miRNAs, or the downregulation of the pro-autophagy miRNAs. This process promotes the re-
establishment of an epithelial cell state for developing into macrometastasis. Upregulated pro-EMT miRNAs are depicted as large
red icons, while downregulated pro-MET miRNAs are depicted as small blue icons. EMT: epithelial-to-mesenchymal transition; MET:
mesenchymal-to-epithelial transition
