Page 57 - Read Online

Page 8 of 10 Chien et al. J Cancer Metastasis Treat 2019;5:66 I http://dx.doi.org/10.20517/2394-4722.2019.016

4. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008;451:1069-75.
5. Berry DL, Baehrecke EH. Autophagy functions in programmed cell death. Autophagy 2008;4:359-60.
6. Liu EY, Ryan KM. Autophagy and cancer--issues we need to digest. J Cell Sci 2012;125:2349-58.
7. Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nature reviews. Cancer 2007;7:961-67.
8. Buccarelli M, Marconi M, Pacioni S, De Pascalis I, D'Alessandris QG, et al. Inhibition of autophagy increases susceptibility of glioblastoma
stem cells to temozolomide by igniting ferroptosis. Cell Death Dis 2018;9:841.
9. Zinn PO, Singh SK, Kotrotsou A, Abrol S, Thomas G, et al. Distinct Radiomic Phenotypes Define Glioblastoma TP53-PTEN-EGFR
Mutational Landscape. Neurosurgery 2017;64:203-10.
10. Hatanpaa KJ, Burma S, Zhao D, Habib AA. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and
radioresistance. Neoplasia 2010;12:675-84.
11. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, et al. MDA-9/Syntenin regulates protective autophagy in anoikis-resistant
glioma stem cells. Proc Natl Acad Sci U S A 2018;115:5768-73.
12. Caldera V, Mellai M, Annovazzi L, Valente G, Tessitore L, et al. Stat3 expression and its correlation with proliferation and apoptosis/
autophagy in gliomas. J Onco 2008;2008:219241.
13. Tini P, Belmonte G, Toscano M, Miracco C, Palumbo S, et al. Combined epidermal growth factor receptor and Beclin1 autophagic protein
expression analysis identifies different clinical presentations, responses to chemo- and radiotherapy, and prognosis in glioblastoma. Biomed
Res Int 2015;2015:208076.
14. Muller-Greven G, Carlin CR, Burgett ME, Ahluwalia MS, Lauko A, et al. Macropinocytosis of Bevacizumab by Glioblastoma Cells in the
Perivascular Niche Affects their Survival. Clin Cancer Res 2017;23:7059-71.
15. Takeuchi H, Kanzawa T, Kondo Y, Kondo S. Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma
cells. Br J Cancer 2004;90:1069-75.
16. Vehlow A, Cordes N. DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy.
Autophagy 2019;15:1487-88.
17. Fan QW, Weiss WA. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. Methods Mol Biol 2012;821:349-
59.
18. Shingu T, Holmes L, Henry V, Wang Q, Latha K, et al. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine
kinase inhibitors in glioma tumor-initiating cells. J Transl Med 2016;14:46.
19. Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, et al. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to
antiangiogenic treatment in glioblastoma. Cancer Res 2012;72:1773-83.
20. Azad MB, Gibson SB. Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies. Ann
N Y Acad Sci 2010;1210:8-16.
21. Womeldorff M, Gillespie D, Jensen RL. Hypoxia-inducible factor-1 and associated upstream and downstream proteins in the
pathophysiology and management of glioblastoma. Neurosurg Focus 2014;37:E8.
22. Verbaanderd C, Maes H, Schaaf MB, Sukhatme VP, Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-chloroquine and
hydroxychloroquine as anti-cancer agents. Ecancermedicalscience 2017;11:781.
23. Yan Y, Xu Z, Dai S, Qian L, Sun L, et al. Targeting autophagy to sensitive glioma to temozolomide treatment. J Exp Clin Cancer Res
2016;35:23.
24. Chang KY, Tsai SY, Wu CM, Yen CJ, Chuang BF, et al. Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays
potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin Cancer Res 2011;17:7116-26.
25. Chang L, Graham PH, Hao J, Ni J, Bucci J, et al. PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate
cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways. Cell Death Dis 2014;5:e1437.
26. Golden EB, Cho HY, Jahanian A, Hofman FM, Louie SG, et al. Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by
blocking autophagy. Neurosurg Focus 2014;37:E12.
27. Zhang WB, Wang Z, Shu F, Jin YH, Liu HY, et al. Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in
glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem 2010;285:40461-71.
28. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide
versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet
Oncol 2009;10:459-66.
29. Wick W, Weller M, van den Bent M, Sanson M, Weiler M, et al. MGMT testing--the challenges for biomarker-based glioma treatment. Nat
Rev Neurol 2014;10:372-85.
30. Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, et al. A pathway of targeted autophagy is induced by DNA damage in budding
yeast. Proc Natl Acad Sci U S A 2017;114:E1158-67.
31. Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, et al. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U
S A 2015;112:773-8.
32. Knizhnik AV, Roos WP, Nikolova T, Quiros S, Tomaszowski KH, et al. Survival and death strategies in glioma cells: autophagy, senescence
and apoptosis triggered by a single type of temozolomide-induced DNA damage. PloS one 2013;8:e55665.
33. Kanzawa T, Bedwell J, Kondo Y, Kondo S, Germano IM. Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide. J
Neurosurg 2003;99:1047-52.
34. Filippi-Chiela EC, Bueno e Silva MM, Thome MP, Lenz G. Single-cell analysis challenges the connection between autophagy and
senescence induced by DNA damage. Autophagy 2015;11:1099-113.
35. Chang KY, Hsu TI, Hsu CC, Tsai SY, Liu JJ, et al. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide
resistance in glioblastoma, which is independent of O(6)-methylguanine-DNA methyltransferase. Redox Biol 2017;13:655-64.
36. Chang KY, Huang CT, Hsu TI, Hsu CC, Liu JJ, et al. Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to