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Yagawa et al. Cancer immunity and hyperthermia

regard to biological effects are found until now. DECLARATIONS

Overall, hyperthermia is considered a convenient Authors’ contributions
therapeutic method so long as it is used appropriately. Designed and wrote the manuscripts: Y. Yagawa
Paradoxically, the safety of hyperthermia is maintained Conducted IFN-γ and IL-2 production assays: Y.
by avoiding excess irradiation with the purpose of deep Kobayashi
heating, because it is still difficult to aggregate the heat Provided suggestions on the revision of the
effect only in cancer tissue. By using hyperthermia manuscripts: M. Yamamoto
in combination with chemotherapy or radiotherapy, Built Figures 1, 4 and 5 and revised the manuscript:
the dose of these therapies may be reduced to ease K. Tanigawa
their side-effects without reducing therapeutic effects,
because hyperthermia has the potential to augment Financial support and sponsorship
the effect of chemotherapy or radiotherapy in a less None.
invasive manner.
Conflicts of interest
CONCLUSION There are no conflicts of interest.
Patient consent
This report shows that hyperthermia increases the Not applicable.
advantage of the following biological features. Heat
stress lowers the survival rate of all cells, but normal Ethics approval
tissues are better able to tolerate this than cancerous Not applicable.
tissues. Heat has a potential to augment immune
responses while decreasing immune suppression.
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