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Special Issue
Circulating Tumor Cells: Diagnostics and
Clinical Applications
Guest Editor:
Prof. Pravin D. Potdar
Head, Department of
Molecular Medicine and
Biology, Jaslok Hospital and
Research Centre, Mumbai
400026, India.
E-mail:
ppravin012@gmail.com
Special Issue Introduction
Major cause of relatively high mortality in cancer patients are due to the
dissemination of tumor cells from primary tumor to distance organs which cannot
be detected early by present imaging technology. However, one of the most
promising development in cancer diagnosis & therapies is an introduction of
Circulating Tumor Cells (CTCs) as a minimally invasive technology for monitoring
the therapies of metastatic cancers. CTCs are originating from shredding of solid
tumor cells in blood circulation and represent the tumour counterpart in vivo.
Enumeration and molecular profiling of these CTCs in peripheral blood of
metastatic cancer patients allow clinicians to monitor intensity of metastasis
cancer along with tumour cell phenotypes for using molecular targeted therapy
for better cure. These liquid biopsies allow the characterization of specific
biomarkers of CTCs in metastatic cancer patient more precisely than the old
method of histopathology of biopsy specimen. Therefore this technology may
revolutionize cancer detection and possible therapies for metastatic cancer in
near future. However, it remains technically challenging because of very low
concentration of CTCs in blood stream of cancer patients and there is a need for
establishing well standardised protocol for enumeration of these CTCs according
to their original phenotype. Molecular characterization of CTCs is one of the most
active areas of translational cancer research and soon, CTCs characterization will
contribute to have very specific targeted therapies for metastatic cancer patients
and become the hallmark of Personalized Medicine. This special issue on
“Circulating Tumor Cells: - Diagnostics & clinical application” mainly discusses an
important technical and theoretical aspects of CTCs technologies, including
validation of enumeration of CTCs protocols and establishment of various
biomarkers involved in cancer development by innovated molecular
technologies. It also further evaluates an exact mechanism of metastasis process
of various cancers for more specific treatment and cure of this disease.
Benefits
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accessed and downloaded from the journal website without any
fee.
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(COPE Ethical Guidelines for Peer Reviewers) and ensure rigorous
peer review process.
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than 173 countries worldwide.
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various channels.
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