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               Availability of data and materials
               Not applicable.

               Financial support and sponsorship
               ThisworkissupportedbytheNationalNaturalScienceFoundationofChina(U1913208), ScienceandTechnol-
               ogy Program of Tianjin (21JCZDJC00170), Tianjin Key Medical Discipline (Specialty) Construction Project
               (TJYXZDXK052B), Tianjin Health Research Project (TWJ2022XK024), and Excellent Youth Team of Central
               Universities (NKU63231196).

               Conflicts of interest
               All authors declared that there are no conflicts of interest.


               Ethical approval and consent to participate
               ThestudywasapprovedbythelocalethicscommitteeofTianjinHuanhuHospital(No. 2019-56)andregistered
               in the Chinese Clinical Trial Registry (ChiCTR1900022655). The informed parental/caregiver consent was
               obtained for all patients in accordance with the Declaration of Helsinki.


               Consent for publication
               Not applicable.


               Copyright
               © The Author(s) 2024.



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