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Mantovani et al. Hepatoma Res 2020;6:78 Hepatoma Research
DOI: 10.20517/2394-5079.2020.75

Review Open Access

Prevalence and incidence of intra- and extrahepatic
complications of NAFLD in patients with type 2

diabetes mellitus

Alessandro Mantovani , Giorgia Beatrice , Roberta Stupia , Andrea Dalbeni 2
2
1
1
1 Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona,
Verona 37126, Italy.
2 Section of General Medicine, Hypertension and Liver Unit, University and Azienda Ospedaliera Universitaria Integrata of
Verona, Verona 37126, Italy.
Correspondence to: Dr. Alessandro Mantovani, Section of Endocrinology, Diabetes and Metabolism, University and Azienda
Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, Verona 37126, Italy. E-mail: alessandro.mantovani@univr.it
How to cite this article: Mantovani A, Beatrice G, Stupia R, Dalbeni A. Prevalence and incidence of intra- and extrahepatic
complications of NAFLD in patients with type 2 diabetes mellitus. Hepatoma Res 2020;6:78.
http://dx.doi.org/10.20517/2394-5079.2020.75

Received: 2 Aug 2020 First Decision: 24 Aug 2020 Revised: 12 Sep 2020 Accepted: 14 Oct 2020 Published: 6 Nov 2020
Academic Editor: Stefano Bellentani Copy Editor: Cai-Hong Wang Production Editor: Jing Yu
Received: First Decision: Revised: Accepted: Published:

Science Editor: Copy Editor: Production Editor: Jing Yu
Abstract
Nonalcoholic fatty liver disease (NAFLD) is linked to abdominal obesity, insulin resistance and type 2 diabetes
mellitus (T2DM). The association of NAFLD with T2DM is bidirectional. In fact, evidence suggests that
abdominal obesity, T2DM and metabolic syndrome play a part in the development and progression of NAFLD.
Alternatively, NAFLD is associated with an increased risk of having T2DM and metabolic syndrome. According
to this background, it is unsurprising that patients with T2DM patients also have a higher prevalence of NAFLD
than those with no T2DM, as well as an increased risk of developing liver-related and extrahepatic complications,
mainly cardiovascular and renal diseases. Seeing the relationship of NAFLD with insulin resistance, obesity and
T2DM, recent consensus proposes a change in nomenclature from NAFLD to metabolic associated fatty liver
disease. In this review, we will discuss the prevalence and incidence of NAFLD (as detected by imaging techniques
or liver biopsy) in patients with type T2DM with particular regard to hepatic and extrahepatic complications.

Keywords: Nonalcoholic fatty liver disease; NASH, metabolic associated fatty liver disease, diabetes, type 2
diabetes

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
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