Page 67 - Read Online
P. 67

Jiang et al. Hepatoma Res 2019;5:5  I  http://dx.doi.org/10.20517/2394-5079.2018.97                                               Page 11 of 11


                   toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci USA 2008;105:3933-8.
               13.  Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor
                   transactivation domain. Science 1996;274:948-53.
               14.  Pazgier M, Liu M, Zou G, Yuan W, Li C, et al. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and
                   MDMX. Proc Natl Acad Sci USA 2009;106:4665-70.
               15.  Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Reactivation of the p53 tumor suppressor pathway by a stapled p53
                   peptide. J Am Chem Soc 2007;129:2456-7.
               16.  Madden MM, Vera CIR, Song W, Lin Q. Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced
                   intramolecular 1, 3-dipolar cycloaddition reaction. Chem Commun 2009:5588-90.
               17.  Boal AK, Guryanov I, Moretto A, Crisma M, Lanni EL, et al. Facile and e-selective intramolecular ring-closing metathesis reactions
                   in 310-helical peptides: a 3D structural study. J Am Chem Soc 2007;129:6986-7.
               18.  Schievano E, Bisello A, Chorev M, Bisol A, Mammi S, et al. Aib-rich peptides containing lactam-bridged side chains as models of the
                   310-helix. J Am Chem Soc 2001;123:2743-51.
               19.  Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, et al. A stapled BID BH3 helix directly binds and activates BAX. Mol Cell
                   2006;24:199-210.
               20.  Zhang F, Sadovski O, Xin SJ, Woolley GA. Stabilization of folded peptide and protein structures via distance matching with a long,
                   rigid cross-linker. J Am Chem Soc 2007;129:14154-5.
               21.  Ousaka N, Inai Y, Kuroda R. Chain-terminus triggered chiral memory in an optically inactive 310-helical peptide. J Am Chem Soc
                   2008;130:12266-7.
               22.  Cantel S, Le Chevalier Isaad A, Scrima M, Levy JJ, DiMarchi RD, et al. Synthesis and conformational analysis of a cyclic peptide
                   obtained via i to i+ 4 intramolecular side-chain to side-chain azide-alkyne 1, 3-dipolar cycloaddition. J Org Chem 2008;73:5663-74.
               23.  Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, et al. Integrative analysis of complex cancer genomics and clinical profiles using
                   the cBioPortal. Sci Signal 2013;6:pl1.
               24.  Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, et al. The cBio cancer genomics portal: an open platform for exploring
                   multidimensional cancer genomics data. Cancer Discov 2012;2:401-4.
               25.  He W, Mazzuca P, Yuan W, Varney K, Bugatti A, et al. Identification of amino acid residues critical for the B cell growth-promoting
                   activity of HIV-1 matrix protein p17 variants. Biochim Biophys Acta Gen Subj 2019;1863:13-24.
               26.  He W, Yan J, Sui F, Wang S, Su X, et al. Turning a luffa protein into a self-assembled biodegradable nanoplatform for multitargeted
                   cancer therapy. ACS Nano 2018;12:11664-77.
               27.  Dolcetti R, Giagulli C, He W, Selleri M, Caccuri F, et al. Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis. Proc
                   Natl Acad Sci U S A 2015;112:14331-6.
               28.  Liu M, Li C, Pazgier M, Li C, Mao Y, et al. D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of
                   malignant neoplasms. Proc Natl Acad Sci USA 2010;107:14321-6.
               29.  Yan J, He W, Yan S, Niu F, Liu T, et al. Self-assembled peptide-lanthanide nanoclusters for safe tumor therapy: overcoming and
                   utilizing biological barriers to peptide drug delivery. ACS Nano 2018;12:2017-26.
               30.  Niu F, Yan J, Ma B, Li S, Shao Y, et al. Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating
                   peptide for acute myeloid leukemia therapy. Biomaterials 2018;167:132-42.
               31.  Yu M, Yan J, He W, Li C, Ma PX, et al. Synthetic θ-defensin antibacterial peptide as a highly efficient nonviral vector for redox-
                   responsive miRNA delivery. Adv Biosys 2017;1:1700001.
               32.  Bu B, Tong X, Li D, Hu Y, He W, et al. N-terminal acetylation preserves α-synuclein from oligomerization by blocking intermolecular
                   hydrogen bonds. ACS Chem Neurosci 2017;8:2145-51.
               33.  Lane DP. Cancer. p53, guardian of the genome. Nature 1992;358:15-6.
               34.  Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and
                   inhibits p53-mediated transactivation. cell 1992;69:1237-45.
               35.  Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997;387:299-303.
               36.  Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and
                   degradation of p53. Proc Natl Acad Sci USA 2003;100:12009-14.
               37.  Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000;408:307-10.
               38.  Khoo KH, Verma CS, Lane DP. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov
                   2014;13:217-36.
               39.  Burgess A, Chia KM, Haupt S, Thomas D, Haupt Y, et al. Clinical overview of MDM2/X-targeted therapies. Front Oncol 2016;6:7.
               40.  Shangary S, Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel
                   approach for cancer therapy. Annu Rev Pharmacol Toxicol 2009;49:223-41.
               41.  Tan BX, Liew HP, Chua JS, Ghadessy FJ, Tan YS, et al. Anatomy of Mdm2 and Mdm4 in evolution. J Mol Cell Biol 2017;9:3-15.
               42.  Zhan C, Lu W. Peptide activators of the p53 tumor suppressor. Curr Pharm Des 2011;17:603-9.
               43.  Liu M, Pazgier M, Li C, Yuan W, Li C, et al. A left-handed solution to peptide inhibition of the p53-MDM2 interaction. Angew Chem
                   Int Ed Engl 2010;49:3649-52.
   62   63   64   65   66   67   68   69   70   71   72