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Yang et al. Hepatoma Res 2019;5:13 I http://dx.doi.org/10.20517/2394-5079.2019.04 Page 5 of 9

Figure 2. Tumor response rate of comparison TACE with RFA vs. TACE alone

Figure 3. Six-month survival rate of TACE with RFA vs. TACE alone

Figure 4. One-year survival rate of TACE with RFA vs. TACE alone

survival rate [RR = 1.257, 95%CI: 1.128-1.401, P < 0.001], 1-year overall survival rate [RR = 1.412, 95%CI:
1.249-1.596, P < 0.001], eighteen-month survival rate [RR = 1.792, 95%CI: 1.423-2.256, P < 0.001], and 2-year
overall survival rate [RR = 1.675, 95%CI: 1.233-2.275, P = 0.001]. To our knowledge this study is the first
meta-analysis to disclose the efficacy of TACE combined with RFA for HCC tumors larger than 5 cm,
compared with TACE alone. The publication bias of this study was evaluated using the symmetry level of the
funnel plot . In the analysis of the tumor response rate and survival rate, the symmetry of the shape of the
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