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Yang et al. Hepatoma Res 2019;5:13 Hepatoma Research
DOI: 10.20517/2394-5079.2019.04

Original Article Open Access

Transarterial chemoembolization combined
with radiofrequency ablation in the treatment of
hepatocellular carcinomas larger than 5 cm

Yi Yang , Zhuo-Min Lv , Min Yan , Hong-Xin Zhang , Yong Long ,Wei-Lu Zhang 2,#
2
1
1
2,#
1,#
1 Department of Pain Treatment, Tangdu Hospital of the Fourth Military Medical University, Xi’an 710038, China.
2 Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,
the Fourth Military Medical University, Xi’an 710032, China.
# Authors contributed equally to this work.
Correspondence to: Dr. Wei-Lu Zhang and Dr. Yong Long, Department of Epidemiology, Ministry of Education Key Lab of Hazard
Assessment and Control in Special Operational Environment, the Fourth Military Medical University, No. 169 Changle west road, Xi’an
710032, China. E-mail: zhangweilu@126.com; longyong@fmmu.edu.cn; Hong-Xin Zhang, Department of Pain Treatment, Tangdu
Hospital of the Fourth Military Medical University, No. 569 Xinsi Road, Xi’an 710038, China. E-mail: zhhxtdjr@163.com

How to cite this article: Yang Y, Lv ZM, Yan M, Zhang HX, Long Y, Zhang WL. Transarterial chemoembolization combined with
radiofrequency ablation in the treatment of hepatocellular carcinomas larger than 5 cm. Hepatoma Res 2019;5:13.
http://dx.doi.org/10.20517/2394-5079.2019.04

Received: 8 Jan 2019 First Decision: 18 Feb 2019 Revised: 11 Mar 2019 Accepted: 12 Mar 2019 Published: 26 Apr 2019

Science Editor: Guang-Wen Cao Copy Editor: Cai-Hong Wang Production Editor: Huan-Liang Wu

Abstract
Aim: This meta-analysis was designed to compare the effectiveness of the combination of transarterial
chemoembolization (TACE) and radiofrequency ablation (RFA) vs. that of TACE alone in hepatocellular carcinoma
(HCC) tumors larger than 5 cm.

Methods: PUBMED, CNKI, and CBM were searched for all related randomized controlled trials (RCTs) up until
October 22, 2018. Eleven studies were identified that compared TACE with RFA vs. TACE alone for HCC treatment.
Tumor response rate, the proportion of patients with either complete or partial shrinkage of tumors, and survival rate
were the major evaluation indices.

Results: Meta-analysis data revealed that TACE with RFA showed significantly better tumor response rate (risk ratio
(RR) = 1.452, 95% confidence interval (CI): 1.308-1.610, P < 0.001) and 1-year overall survival rate (RR = 1.412, 95%
CI: 1.249-1.596, P < 0.001) than that of TACE alone treatment.

Conclusion: The data of our study indicates that TACE combined with RFA in the treatment of HCC larger than 5 cm
is an effective comprehensive interventional therapy.

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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