Page 49 - Read Online

Page 8 of 10 Chen et al. Hepatoma Res 2018;4:4 I http://dx.doi.org/10.20517/2394-5079.2017.50

investigators to continue. Last but not least, we thank all the study participants whose longstanding personal
dedication and commitment have been paramount to make this study possible.

Authors’ contributions
Current co-principle investigators of QBC: Chen TY, Tu H
Former co-principle investigators of QBC: Qian GS, Lu PX
Cohort maintenance and data collection: Sun Y, Wang JB, Lu PX, Xue XF, Wu Y, Zhang QN, Lu JQ
Molecular and biochemistry experiments of QBC: Jin Y, Wu YQ, Gan Y
Collaborative researches on aflatoxin and HBV: Kensler TW, Groopman JD
Cleaned raw data, performed statistical analysis and wrote the preliminary manuscript: Fan CS
Revised the manuscript and added important intellectual contents into the manuscript: Chen TY, Qian GS,
Tu H

Data source and availability
Data collection documents and bio-samples are stored at QDLCI and SCI. Interested research teams can
contact with Dr. Tao-Yang Chen at E-mail: ty110@263.net, and Dr. Hong Tu at E-mail: tuhong@shsci.org.

Financial support and sponsorship
This work was supported by Chinese National Key Project of Eighth Five-year (grant number 859140303,
GQ); Chinese National Key Project of Ninth Five-year (grant number 969060107, GQ); Chinese National Key
Project Specialized for Infectious Diseases (grant numbers 2008ZX10002-015, HT; 2008ZX10002-018, TC;
2012ZX10002008-003, TC; 2012ZX10002-008-002, HT; 2017ZX10201201-006-002, TC; 2017ZX10201201-008-
003, HT); National Institute of Environmental Health Sciences grant PO1 (grant number ES06052 USA, JDG
and TWK); Chinese National Key Research Projects for Precision Medicine (grant number 2017YFC0908103,
JL); Research Funding for Young Medical Talents of Nantong Municipal Commission of Health and Family
Planning (grant number WQZ2015007, CF).

Conflict of interest
There are no conflicts of interest.

Patient consent
All participants signed the informed consent before study.

Ethics approval
The study protocol and informed consent were approved by the human subjects review committees at the
Qidong Liver Cancer Institute, Shanghai Cancer Institute and John Hopkins University.

Copyright
© The Author(s) 2018.

REFERENCES
1. Li JY, Liu BQ, Li GY, Chen ZJ, Sun XI, Rong SD. Atlas of cancer mortality in the People’s Republic of China. An aid for cancer control
and research. Int J Epidemiol 1981;10:127-33.
2. Chen JG, Zhu J, Parkin DM, Zhang YH, Lu JH, Zhu YR, Chen TY. Trends in the incidence of cancer in Qidong, China, 1978-2002. Int
J Cancer 2006;119:1447-54.
3. Lu JH, Li WG, Jiang ZY, Ni ZP, Huang F. Prospective survey on relationship between HBsAg carrier status and liver cancer. J Med Res
1983;(5):13-4.
4. Wei YP, Lu PX, Huang QS, Lu SX, Zhang QN, Gu JP. Prospective study with 518 participants on relationship between HBsAg status
and liver cancer incidence. J Clin Hepatol 1992;8:77-8.
5. Wang YB, Lan LZ, Ye BF, Xu YC, Li WG. Study on relationship between geographical distribution of liver cancer, climate and