Page 112 - Read Online
P. 112
Link et al. Roles of p53 in extrinsic factor-induced liver carcinogenesis
mechanisms to induce oxidative stress in human hepatoma Huh7 1998;438:258-62.
cells. Viruses 2015;7:2745-70. 124. Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL. p53-dependent
116. Marusawa H, Hijikata M, Chiba T, Shimotohno K. Hepatitis C transcriptional repression of p21(waf1) by hepatitis C virus NS3. J
virus core protein inhibits Fas- and tumor necrosis factor alpha- Gen Virol 2001;82:2235-41.
mediated apoptosis via NF-kappaB activation. J Virol 1999;73:4713- 125. Deng L, Nagano-Fujii M, Tanaka M, Nomura-Takigawa Y, Ikeda M,
20. Kato N, Sada K, Hotta H. NS3 protein of hepatitis C virus associates
117. Liu J, Wang Z, Tang J, Tang R, Shan X, Zhang W, Chen Q, Zhou F, with the tumour suppressor p53 and inhibits its function in an NS3
Chen K, Huang A, Tang N. Hepatitis C virus core protein activates sequence-dependent manner. J Gen Virol 2006;87:1703-13.
Wnt/beta-catenin signaling through multiple regulation of upstream 126. Sakamuro D, Furukawa T, Takegami T. Hepatitis C virus
molecules in the SMMC-7721 cell line. Arch Virol 2011;156:1013- nonstructural protein NS3 transforms NIH 3T3 cells. J Virol
23. 1995;69:3893-6.
118. Kao CF, Chen SY, Chen JY, Wu Lee YH. Modulation of p53 127. Wang AG, Lee DS, Moon HB, Kim JM, Cho KH, Choi SH, Ha HL,
transcription regulatory activity and post-translational modification Han YH, Kim DG, Hwang SB, Yu DY. Non-structural 5A protein
by hepatitis C virus core protein. Oncogene 2004;23:2472-83. of hepatitis C virus induces a range of liver pathology in transgenic
119. Feng S, Li M, Zhang J, Liu S, Wang Q, Quan M, Zhang M, Cheng J. mice. J Pathol 2009;219:253-62.
Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core 128. Ghosh AK, Majumder M, Steele R, Meyer K, Ray R, Ray RB.
protein via the sirt1-p53-bax pathway. Virus Genes 2015;51:338-46. Hepatitis C virus NS5A protein protects against TNF-alpha
120. He QQ, Cheng RX, Sun Y, Feng DY, Chen ZC, Zheng H. mediated apoptotic cell death. Virus Res 2000;67:173-8.
Hepatocyte transformation and tumor development induced 129. Yeh CT, Chang MH, Shyu WC, Chang ML, Yang PY, Tsao
by hepatitis C virus NS3 c-terminal deleted protein. World J ML, Lai HY. Characterization of a HCV NS5A protein derived
Gastroenterol 2003;9:474-8. from a patient with hepatoma. Biochem Biophys Res Commun
121. Lu L, Wei L, Peng G, Mu Y, Wu K, Kang L, Yan X, Zhu Y, Wu 2005;327:516-22.
J. NS3 protein of hepatitis C virus regulates cyclooxygenase-2 130. Chung YL, Sheu ML, Yen SH. Hepatitis C virus NS5A as a
expression through multiple signaling pathways. Virology potential viral Bcl-2 homologue interacts with Bax and inhibits
2008;371:61-70. apoptosis in hepatocellular carcinoma. Int J Cancer 2003;107:65-73.
122. Feng DY, Sun Y, Cheng RX, Ouyang XM, Zheng H. Effect of 131. Majumder M, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C
hepatitis C virus nonstructural protein NS3 on proliferation virus NS5A physically associates with p53 and regulates p21/waf1
and MAPK phosphorylation of normal hepatocyte line. World J gene expression in a p53-dependent manner. J Virol 2001;75:1401-7.
Gastroenterol 2005;11:2157-61. 132. Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ,
123. Ishido S, Hotta H. Complex formation of the nonstructural protein Kato N, Omata M, Chang FY, Lee SD. HCV NS5A interacts with p53
3 of hepatitis C virus with the p53 tumor suppressor. FEBS Lett and inhibits p53-mediated apoptosis. Oncogene 2002;21:4801-11.
104 Hepatoma Research ¦ Volume 3 ¦ June 6, 2017