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Table 2: Comparison of baseline serum chemistry parameters between males and females respectively in the < 50 and > 50
year-aged patient samples
< 50 years sample (n = 55) > 50 years sample (n = 45)
Student’s Student’s
Male (n = 34) Female (n = 21) P value Male (n = 21) Female (n = 24) P value
T-test T-test
Age (years) 38.2 ± 5.7 38.1 ± 7.1 0.053 0.958 57.5 ± 5.6 58.2 ± 4.1 -0.467 0.643
9
PLTs (× 10 /L) 212 ± 38 235 ± 55 -1.235 0.222 187 ± 54 206 ± 78 -0.901 0.373
Hb (g/dL) 15.5 ± 1.37 13.8 ± 1.1 4.371 0 15 ± 1 13.74 ± 1.58 3.021 0.005
9
WBC (× 10 /L) 6 ± 1.5 6 ± 1.48 0.077 0.939 5.8 ± 1.74 5.1 ± 1.3 1.409 0.168
AST (U/L) 55 ± 54 43 ± 35 0.877 0.384 56 ± 27 66 ± 49 -0.879 0.384
ALT (U/L) 98 ± 82 62 ± 52 1.769 0.083 89 ± 48 80 ± 73 0.474 0.638
GGT (U/L) 105 ± 91 27 ± 20 4.583 0 75 ± 75 54 ± 34 1.194 0.239
ALP(U/L) 85 ± 42 97 ± 52 -0.361 0.724 94 ± 28 100 ± 45 -0.303 0.766
Total bilirubin (mg/dL) 0.94 ± 0.47 0.77 ± 0.25 1.294 0.203 1 ± 0.3 0.8 ± 0.2 1.659 0.108
INR 1.1 ± 0.3 1 ± 0.0 1.053 0.301 1.1 ± 0.2 1 ± 0.1 1.503 0.16
Uric acid (mg/dL) 5.6 ± 1.3 4.6 ± 0.7 1.032 0.314 5.6 ± 1.2 4.61 ± 1.1 3.036 0.006
AFP (ng/mL) 5.2 ± 2.9 4.1 ± 3.2 0.694 0.498 1.4.5 ± 13.2 8.3 ± 5 1.194 0.272
HCV RNA (log 10 UI/mL) 5.66 ± 0.71 5.63 ± 0.75 0.094 0.926 5.86 ± 0.52 5.98 ± 0.48 -0.737 0.466
Cryoglobulins (+/-) 3/31 2/19 Chi = 0.008 0.93 0/21 4/20 Chi = 3.84 0.05
Ferritin (ng/mL) 307 ± 77 26 ± 60 1.363 0.183 310 ± 191 357 ± 130 0.997 0.331
Data are shown as mean ± SD. PLT: platelet; Hb: hemoglobin; WBC: white blood cell; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT:
gamma-glutamyltransferase; ALP: alkaline phosphatase; INR: international normalized ratio; AFP: alpha-fetoprotein; HCV: hepatitis C virus

Table 3: Degree of fibrosis and steatosis in the whole sample considering males and females, value of the Chi-square test
and the related P value
Whole sample (n = 100)
Male (n = 55) Female (n = 45) Chi-square test P value
Fibrosis, n (%) 0.069 0.966
0-1 34 (61.8%) 28 (62%)
2 12 (21.8%) 9 (20%)
3-4 9 (16.4%) 8 (18%)
Steatosis, n (%)* 0.488 0.921
Assessment 19 (35.85%) 13 (31%)
Light 13 (24.5%) 12 (28.6%)
Mild 19 (35.85%) 16 (38%)
Advanced 2 (3.8%) 1 (2.4%)
*Steatosis degree has been assessed only in 95 subjects (53 males and 42 females), resulting 5 ultrasonographic investigations poorly reliable

Table 4: Degree of fibrosis and steatosis considering males and females, value of the Chi-square test and the related P
value respectively in the < 50 and > 50 year-aged patient samples
< 50 years sample (n = 55) > 50 year sample (n = 45)
Chi-square Chi-square
Male (n = 34) Female (n = 21) test P value Male (n = 21) Female (n = 24) test P value
Fibrosis, n (%) 4.954 0.0839 0.145 0.929
0-1 27 (79.4%) 21 (100%) 7 (33.3%) 7 (29.2%)
2 4 (11.8%) 0 (0%) 8 (38.1%) 9 (37.5%)
3-4 3 (8.8%) 0 (0%) 6 (28.6%) 8 (33.3%)
Steatosis, n (%)* 1.8127 0.612 3.1 0.375
Assessment 11 (33.3%) 9 (45%) 8 (40%) 4 (18.2%)
Light 8 (24.2%) 5 (25%) 5 (25%) 7 (31.8%)
Mild 12 (36.4%) 6 (30%) 7 (35%) 10 (45.5%)
Advanced 2 (6.1) 0 (0%) 0 (0%) 1 (4.5%)
*Steatosis degree has been assessed only in 95 subjects (33 males < 50 years, 20 females < 50 years, 20 males > 50 years, and 22 females > 50 years),
resulting 5 ultrasonographic investigations poorly reliable

Assessment of virological response In the whole sample < 50 years patients showed a
Forty patients reached a SVR (SVR rate 40%); and 60 significant rate of SVR (P = 0.040) [Table 6], due to
patients were negative at the end of the treatment < 50 years women who achieved significant higher
(ETVR rate 60%), but among these 20 fell in the later rates of both ETVR (P = 0.001) and SVR (P = 0.01)
24 weeks, with a 33.3% relapse rate. compared to males of similar age [Table 7, Figures 1

Hepatoma Research | Volume 2 | May 6, 2016 125