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Calinescu et al. Hepatoma Res 2021;7:59 https://dx.doi.org/10.20517/2394-5079.2021.26 Page 13 of 17

CONCLUSION
Pediatric LT in the oncological setting has evolved during the last two decades into an effective procedure
for a selected subgroup of patients. Indications are quite clear in HBL but still need validation in pediatric
HCC patients. This review focuses on indications and limitations in the LT treatment of unresectable
pediatric HBL and HCC. The ongoing PHITT trial will probably provide evidence-based guidelines for the
LT management of pediatric patients with unresectable HBL and HCC.

DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the study, performed data analysis and
interpretation, finally approved the version to be published and agreed to be accountable for all aspects of
the work: Calinescu AM, Héry G, Branchereau S, de Ville de Goyet J
Performed the draft: Calinescu AM, de Ville de Goyet J
Critical revision of the intellectual content: de Ville de Goyet J, Branchereau S, Héry G

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2021.

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